From: Lymphatic vessel density as a prognostic indicator in Asian NSCLC patients: a meta-analysis
Author-year (study period) Country | Sample number | Sex | Median follow-up period (months) | Age: mean age or range | Histology | Histological type | TNM stage | Lymphatic endothelium markers | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Males | Females | ADC | SCC | LCC | Others | |||||||
Kitano-2017 (1988–2010) Japan [33] | 89 | 64 | 25 | range 10–153 | < 60 y 25 ≥60 y 64 | NSCLC | 53 | 36 | 0 | 0 | II 40 III + IV 49 | VEGFR-3 |
Nunomiya-2014 (2008–2011) Japan [25] | 58 | 50 | 8 | ND | 71.3 y | NSCLC 40 SCLC 14 Others 4 | ND | ND | ND | ND | I + II 20 III + IV 37 | LYVE-1 |
Hao-2014 (2004–2012) China [34] | 140 | 72 | 68 | ND | ≤65 y 56 > 65 y 84 | NSCLC | 36 | 39 | 28 | 4 | I–IIIA | LYVE-1 |
Zhang-2012 (2003–2006) China [22] | 65 | 38 | 27 | ND | 51.5 y (range 32–76 y) < 55 y 26 ≥55 y 39 | ADC | 65 | 0 | 0 | 0 | I + II 38 III + IV 27 | D2–40 |
Dai-2011 (1999–2003) China [35] | 98 | ND | ND | 37.53 ± 4.05 | ND | NSCLC | 59 | 39 | 0 | 0 | ND | Podoplanin |
Yamashita-2010 (1993–2000) Japan [36] | 117 | 77 | 40 | 68.7 | 67.8 y (range 47–85 y) < 68 y 67 ≥68 y 50 | Stage I NSCLC | 78 | 31 | 6 | 2 | IA 58 IB 59 | VEGFR-3 |
Chen-2010 (1999–2001) China [37] | 52 | 41 | 11 | ND | 51.9 y (range 29–77 y) < 60 y 31 ≥60 y 21 | NSCLC | 16 | 23 | 0 | 13 | I + II 33 III 19 | LYVE-1 |
Sun-2009 (1995–2004) China [38] | 82 | 63 | 19 | ND | < 55 y 40 ≥55 y 42 | NSCLC | 41 | 31 | 10 | 0 | I + II 48 III + IV 34 | D2–40 |
Iwakiri-2009 (1998–1990) Japan [39] | 215 | 159 | 56 | ND | 63.0 y (range 53–71.8 y) < 63 y 109 ≥63 y 106 | NSCLC | 116 | 82 | 10 | 7 | I + II 147 IIIA 68 | D2–40 |
Kitano-2009 (ND) Japan [23] | 82 | 45 | 37 | ND | 65 y | ADC | 82 | 0 | 0 | 0 | I + II 65 III + IV 17 | Podoplanin |
Kadota-2008 (1998–2002) Japan [24] | 147 | 100 | 47 | ND | 67 y (range 35–82 y) | NSCLC | 93 | 49 | 5 | 0 | I + II 108 III 39 | D2–40 |
Ohta-2006 (1981–2004) Japan [40] | 44 | 23 | 21 | 20 | 64.4 y | NSCLC | 25 | 17 | 0 | 2 | IIIA 35 IIIB 9 | D2–40 |
Kojima-2005 (1981–1998) Japan [26] | 129 | 62 | 67 | 69.9 | 61 y (range 38–78 y) | ADC | 129 | 0 | 0 | 0 | ND | VEGFR-3 |
Chen-2004 (1985–1990) Japan [41] | 206 | 148 | 58 | ND | < 64 y 101 ≥64 y 105 | NSCLC | 116 | 75 | 10 | 5 | I + II 144 IIIA 62 | VEGFR-3 |
Arinaga-2003 (1990–1996) Japan [27] | 180 | 133 | 47 | 54.6 | 65 y (range 35–84 y) | NSCLC | 65 | 101 | 0 | 14 | I + II 130 III 41 | VEGFR-3 |