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Fig. 1 | BMC Pulmonary Medicine

Fig. 1

From: The all age asthma cohort (ALLIANCE) - from early beginnings to chronic disease: a longitudinal cohort study

Fig. 1

Wheeze and asthma phenotypes during childhood and adulthood. About 25–30% of children have at least one episode of wheeze before their 3rd birthday, but considerable clinical heterogeneity exists (broken line box I). Children with transient wheeze become symptom-free before school-age, those with non-atopic asthma after about 8 years of age. However, some, especially those with persistent atopic wheeze and seasonal triggers of wheeze go on to persistent asthma in later childhood and adulthood. Interestingly, girls present with new-onset asthma in significant numbers during adolescence, thereby adding to turning the sex-based bias from male towards female sex. While there is also new-onset-asthma during adulthood, it is unclear whether differences between persistent childhood asthma phenotypes continue throughout transition (broken line box II) into adulthood

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