Characteristics | Establishment cohort (n = 108) | Validation cohort (n = 216) | p Value |
---|---|---|---|
Age-years | 52.8 ± 14.9 | 54.6 ± 17.2 | 0.088 |
Female-no.(%) | 77 (71.3) | 159 (73.6) | < 0.001(0.123) |
WHO group 1 subgroup-no.(%) | |||
Idiopathic PAH | 48 (44.4) | 100 (46.3) | < 0.001(0.147) |
Associated with CTD | 35 (32.4) | 62 (28.7) | < 0.001(0.007) |
Associated with CHD | 10 (9.3) | 25 (11.6) | < 0.001(0.358) |
Associated with PoPH | 7 (6.5) | 10 (4.6) | 0.086(0.414) |
Familial PAH | 3 (2.8) | 6 (2.8) | < 0.001(0.95) |
Other | 5 (4.6) | 13 (6.0) | < 0.001(0.27) |
WHO functional class-no.(%) | |||
I | 9 (8.3) | 21 (9.7) | < 0.001(0.33) |
II | 30 (27.8) | 39 (18.1) | 0.046(0.007) |
III | 55 (50.9) | 131 (60.6) | < 0.001(0.025) |
IV | 14 (13.0) | 25 (11.6) | < 0.001(0.259) |
Systolic BP-mm Hg | 122 ± 23 | 115 ± 19 | 0.005 |
Heart rate-beats/min | 85 ± 15 | 88 ± 17 | 0.151 |
6MWD-m | 338 ± 119 | 309 ± 125 | 0.019 |
N-terminal proBNP -pg/mL | 3268 ± 2431 | 3497 ± 2896 | 0.066 |
Renal insufficiency(yes)-no.(%) | 11 (10.2) | 19 (8.8) | 0.006(0.382) |
DLco of predicted in PFT -% | 53.8 ± 24.9 | 49.7 ± 22.3 | 0.024 |
Peak VO2 in CPET -ml/min/kg | 14.4 ± 9.2 | 12.8 ± 8.6 | 0.036 |
Echocardiography | |||
Right atrial area-cm2 | 21.6 ± 14.9 | 23.1 ± 16.7 | 0.188 |
Pericardial effusion(yes)-no.(%) | 28 (25.9) | 66 (30.6) | < 0.001(0.033) |
Right heart catheterization | |||
Right atrial pressure-mm Hg | 9.7 ± 5.2 | 10.6 ± 5.8 | 0.234 |
Mean pulmonary artery pressure-mm Hg | 45.2 ± 12.8 | 46.7 ± 13.4 | 0.371 |
Pulmonary vascular resistance-WU | 10.5 ± 5.1 | 11.2 ± 6.3 | 0.565 |
Death -no.(%) | 18(16.7) | 40(18.5) | < 0.001(0.096) |
Loss to follow-up -no.(%) | 5(4.6) | 7(3.2) | 0.071(0.122) |