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Table 2 Characteristics of patients in two cohorts

From: A modified risk score in one-year survival rate assessment of group 1 pulmonary arterial hypertension

Characteristics

Establishment cohort (n = 108)

Validation cohort (n = 216)

p Value

Age-years

52.8 ± 14.9

54.6 ± 17.2

0.088

Female-no.(%)

77 (71.3)

159 (73.6)

< 0.001(0.123)

WHO group 1 subgroup-no.(%)

 Idiopathic PAH

48 (44.4)

100 (46.3)

< 0.001(0.147)

 Associated with CTD

35 (32.4)

62 (28.7)

< 0.001(0.007)

 Associated with CHD

10 (9.3)

25 (11.6)

< 0.001(0.358)

 Associated with PoPH

7 (6.5)

10 (4.6)

0.086(0.414)

 Familial PAH

3 (2.8)

6 (2.8)

< 0.001(0.95)

 Other

5 (4.6)

13 (6.0)

< 0.001(0.27)

WHO functional class-no.(%)

 I

9 (8.3)

21 (9.7)

< 0.001(0.33)

 II

30 (27.8)

39 (18.1)

0.046(0.007)

 III

55 (50.9)

131 (60.6)

< 0.001(0.025)

 IV

14 (13.0)

25 (11.6)

< 0.001(0.259)

 Systolic BP-mm Hg

122 ± 23

115 ± 19

0.005

 Heart rate-beats/min

85 ± 15

88 ± 17

0.151

 6MWD-m

338 ± 119

309 ± 125

0.019

 N-terminal proBNP -pg/mL

3268 ± 2431

3497 ± 2896

0.066

 Renal insufficiency(yes)-no.(%)

11 (10.2)

19 (8.8)

0.006(0.382)

 DLco of predicted in PFT -%

53.8 ± 24.9

49.7 ± 22.3

0.024

 Peak VO2 in CPET -ml/min/kg

14.4 ± 9.2

12.8 ± 8.6

0.036

Echocardiography

 Right atrial area-cm2

21.6 ± 14.9

23.1 ± 16.7

0.188

 Pericardial effusion(yes)-no.(%)

28 (25.9)

66 (30.6)

< 0.001(0.033)

Right heart catheterization

 Right atrial pressure-mm Hg

9.7 ± 5.2

10.6 ± 5.8

0.234

 Mean pulmonary artery pressure-mm Hg

45.2 ± 12.8

46.7 ± 13.4

0.371

 Pulmonary vascular resistance-WU

10.5 ± 5.1

11.2 ± 6.3

0.565

 Death -no.(%)

18(16.7)

40(18.5)

< 0.001(0.096)

 Loss to follow-up -no.(%)

5(4.6)

7(3.2)

0.071(0.122)

  1. WHO world health organization, PAH pulmonary arterial hypertension, CTD connective tissue diseasem, CHD congenital heart disease, PoPH portal pulmonary hypertension, 6MWD 6-min walking distance, BNP brain natriuretic peptide, DLco diffusing capacity of lung for carbon monoxide, PFT pulmonary function test, VO2 volume of oxygen, CPET cardiopulmonary exercise testing, WU Wood units