|  | LAA% | D950 | D’15 | D’25 | D’35 |
|---|
FEV1 (%predicted) | −0.45†| 0.27†| 0.02 | 0.21* | 0.21* |
RV/TLC | 0.35†| −0.13 | 0.10 | −0.02 | 0.03 |
DLCO (%predicted) | −0.62†| 0.48†| 0.10 | 0.45†| 0.43†|
DLCO/VA | −0.71†| 0.56†| 0.14 | 0.47†| 0.37†|
- Of 170 subjects enrolled in the present study, this analysis used 144 subjects in which the proxies for inspiration during CT scan were more than 0.8 and less than 1.2 because their CT scans were considered better for assessing structure-function relationships. FEV1 Forced expiratory volume in 1 s, RV/TLC Residual volume / total lung capacity, DLCO Diffusion capacity, VA Alveolar ventilation, LAA% Percent low attenuation area. D950, D’15, D’25, and D’35 are exponents that characterize a power law that governs the cumulative frequency size distribution of LAA clusters that are identified using a threshold of − 950 HU and the 15th, 25th, and 35th percentile of a CT density histogram, respectively. †p < 0.005 and * p < 0.05
