The usefulness of pleural fluid presepsin, C-reactive protein, and procalcitonin in distinguishing different causes of pleural effusions

Table 3 Diagnostic performance of pleural fluid presepsin based on the ROC analysis (n = 132)

	Optimal cut-off point (pg/mL)	Sensitivity (%)	Specificity (%)	+LR	−LR	PPV (%)	NPV (%)	AUC	Accuracy (%)
Emp vs. other	≥754	90.9	74.4	1.39	0.12	24.4	98.9	0.809	75.8
Emp and PE vs. other	≥680	85.2	74.3	3.31	0.20	46.0	95.1	0.803	76.5
Emp, PE, and TB vs. other	≥680	66.7	72.9	2.46	0.46	48.0	85.4	0.728	71.2
PE vs. other (excluding Emp)	≥680	81.3	74.3	3.16	0.25	32.5	96.3	0.785	75.2
Infectious vs. non-infectious	≥680	68.4	74.5	2.68	0.42	52.0	85.4	0.746	72.7

Emp empyema, PE parapneumonic effusions, TB tuberculosis, +LR positive likelihood ratio, −LR negative likelihood ratio PPV positive predictive value, NPV negative predictive value, AUC area under the curve

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