Fig. 1

Characteristics of LPS-induced acute lung injury in C57BL6 mice. Mice were instilled with 50 μL of LPS (4 mg/kg) or saline (controls) on day 0 and were mechanically ventilated 1, 4 or 10 days after ARDS induction. Control mice were mechanical ventilated without prior i.t. instillation. ARDS disease activity was determined via body weight (a) and temperature (b) over the time (controls n = 4 and ARDS group n = 8 per time point, means ± SEM). c–f Lung function parameters resistance (Rrs), elastance (Ers), tissue damping (g) and tissue elastance (h) on day 1, 4 and 10 after ARDS-induction. (controls n = 4, ARDS group n = 6 per time point, means ± SEM). Lung function parameters over a ventilation time of 25 min, exemplary resistance (Rrs) and tissue elastance (H) of treated ARDS-animals and controls on day 1 are depicted in (g) and (h) (controls n = 12, summarized from all time points, ARDS group n = 8, means ± SEM). * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001