Fig. 3

Characteristics of LPS-induced acute lung injury in RAG2^−/− and wildtype mice. ARDS was induced as described before in wildtype (WT) and RAG2^−/− (RAG) mice and animals were mechanically ventilated on day 1, 4 and 10 after ARDS induction. ARDS disease activity was determined via body weight and temperature over the time (a, b). c–f Lung function parameters resistance (Rrs), elastance (Ers), tissue damping (g) and tissue elastance (h) on day 1, 4 and 10 after ARDS-induction. Lung function parameters over a ventilation time of 25 min, exemplary resistance (Rrs) and tissue elastance (h) of treated ARDS-animals and controls on day 1 are depicted in (g) and (h). a–h (n = 8 in each group at each time point, means ± SEM). * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001