Fig. 3
From: WISP1 mediates lung injury following hepatic ischemia reperfusion dependent on TLR4 in mice
WISP1 facilitates the expression of pro-inflammatory cytokines in IBD LPMCs. WT mice in sham and IRI group undergoing ischemia for 60 min and reperfusion for 6 h were treated intraperitoneally with either control IgG antibody or neutralizing WISP1/WISP2 antibody (6 μg/g) 1 h before ischemia and at the onset of reperfusion (n = 6 respectively). qRT-PCR for IL-6 (a and d), TNF-α (b and d), and IL-10 (c) from lung tissues in all groups was performed. ELISA for IL-6 (e and h), TNF-α (f and h), and IL-10 (g) from BALF supernatants in all groups was performed. *p < 0.05 compared with sham group, #p < 0.05 compared with IgG group, data are expressed as mean ± s.e.m. for all samples