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Table 2 Allele distribution of OAS1 polymorphisms in the two populations

From: 2′-5′-Oligoadenylate synthetase 1 polymorphisms are associated with tuberculosis: a case-control study

SNP

Tibetan population

Han population

Cases, n (%)

Controls, n (%)

P #

OR#(95%CI)

Cases, n (%)

Controls, n (%)

P #

OR#(95%CI)

rs2240190(C > A)

 C

941(76.8)

954(79.2)

  

918(81.0)

864(80.0)

  

 A

285(23.2)

250(20.8)

0.128

1.16(0.96–1.41)

216(19.0)

216(20.0)

0.556

0.94(0.76–1.16)

rs1131454(A > G)

 A

778(63.5)

726(60.3)

  

704(62.1)

610(56.5)

  

 G

448(36.5)

478(39.7)

0.110

0.88(0.74–1.03)

430(37.9)

470(43.5)

0.004*

0.78(0.66-0.93)

rs10774671(A > G)

 A

1051(85.7)

984(81.6)

  

896(79.0)

793(73.4)

  

 G

175(14.3)

222(18.4)

0.006*

0.74(0.59-0.92)

238(21.0)

287(26.6)

0.001*

0.72(0.59-0.87)

rs11066453 (A > G)

 A

1171(95.5)

1124(93.4)

  

984(86.8)

937(86.8)

  

 G

55(4.5)

80(6.6)

0.022

0.66(0.47–0.94)

150(13.2)

143(13.2)

0.807

1.03(0.81–1.32)

  1. SNP single nucleotide polymorphism, CI confidence interval, OR odds ratio
  2. #adjusted by sex and age
  3. *Bonferroni correction was performed with p ≤ 0.0125 (0.05/4) considered significant