Table 3 Association between genotype of OAS1 and TB in the two populations
SNP | Genetic model | genotype | Tibetan population | Han population | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Case, n (%) | Controls, n (%) | P # | OR#(95%CI) | Case, n (%) | Controls, n (%) | P # | OR#(95%CI) | |||
rs2240190 (C > A) | Codominant | CC | 361(58.9) | 383(63.6) | – | 1.00 | 368(64.9) | 343(63.5) | ||
CA | 219(35.7) | 188(31.2) | 0.084 | 1.24(0.97–1.58) | 182(32.1) | 178(33.0) | 0.659 | 0.94(0.73–1.22) | ||
AA | 33(5.4) | 31(5.1) | 0.567 | 1.16(0.70–1.94) | 17(3) | 19(3.5) | 0.637 | 0.87(0.44–1.69) | ||
Dominant | AA+CA | 252(41.1) | 219(36.3) | 0.084 | 1.23(0.97–1.55) | 199(35.1) | 197(36.5) | 0.595 | 0.94(0.73–1.20) | |
CC | 361(58.9) | 383(63.6) | – | 1.00 | 368(64.9) | 343(63.5) | ||||
Recessive | AA | 33(5.4) | 31(5.1) | 0.819 | 1.06(0.64–1.76) | 17(3) | 197(36.5) | 0.673 | 0.87(0.44–1.69) | |
CC + CA | 580(94.6) | 571(94.9) | – | 1.00 | 550(73.4) | 521(96.5) | ||||
rs1131454 (A > G) | Codominant | AA | 246(40.1) | 230(38.2) | – | 1.00 | 205(36.2) | 170(31.5) | ||
GA | 286(46.7) | 266(44.2) | 0.971 | 1.01(0.79–1.28) | 294(51.9) | 270(50.0) | 0.353 | 0.88(0.68–1.15) | ||
GG | 81(13.2) | 106(17.6) | 0.054 | 0.71(0.51–1.01) | 68(12.0) | 100(18.5) | 0.001* | 0.52(0.36-0.76) | ||
Dominant | GG + GA | 367(59.9) | 372(61.8) | 0.484 | 0.92(0.73–1.16) | 362(42.0) | 370(68.5) | 0.067 | 0.79(0.61–0.02) | |
AA | 246(40.1) | 230(38.2) | – | 1.00 | 205(36.2) | 170(31.5) | ||||
Recessive | GG | 81(13.2) | 106(17.6) | 0.037 | 0.72(0.52–0.98) | 68(12.0) | 100(18.5) | 0.002* | 0.59(0.42-0.82) | |
AA+GA | 522(86.8) | 496(82.4) | – | 1.00 | 499(88.0) | 440(81.5) | ||||
rs10774671 (A > G) | Codominant | AA | 451(73.6) | 409(68.0) | – | 1.00 | 351(61.9) | 294(92.4) | ||
GA | 149(24.3) | 164(27.2) | 0.148 | 0.83(0.64–1.07) | 194(34.2) | 205(38.0) | 0.053 | 0.78(0.61–1.00) | ||
GG | 13(2.1) | 29(4.8) | 0.008* | 0.41(0.21-0.80) | 22(3.9) | 41(7.6) | 0.001* | 0.40(0.23-0.69) | ||
Dominant | GG + GA | 162(26.4) | 193(32.0) | 0.032 | 0.76(0.59–0.98) | 216(28.4) | 246(45.6) | 0.007 | 0.72(0.56–0.91) | |
AA | 451(73.6) | 409(68.0) | – | 1.00 | 351(61.9) | 294(92.4) | ||||
Recessive | GG | 13(2.1) | 29(4.8) | 0.013 | 0.43(0.22–0.83) | 22(3.9) | 41(7.6) | 0.005* | 0.46(0.27-0.79) | |
AA+GA | 600(97.9) | 573(95.2) | – | 1.00 | 545(96.1) | 499(92.4) | ||||
rs11066453 (A > G) | Codominant | AA | 558(91.0) | 525(87.2) | – | 1.00 | 426(75.1) | 408(75.6) | ||
GA | 55(9.0) | 74(12.3) | 0.060 | 0.70(0.49–1.02) | 132(23.3) | 121(22.4) | 0.550 | 1.09(0.82–1.45) | ||
GG | 0(0) | 3(0.5) | – | – | 9(1.6) | 11(2.0) | 0.592 | 0.78(0.32–1.92) | ||
Dominant | GG + GA | 55(9.0) | 77(12.8) | 0.035 | 0.68(0.47–0.97) | 141(20.2) | 132(24.4) | 0.649 | 1.07(0.81–1.41) | |
AA | 558(91.0) | 525(87.2) | – | 1.00 | 426(75.1) | 408(75.6) | ||||
Recessive | GG | 0(0) | 3(0.5) | – | – | 9(1.6) | 132(24.4) | 0.558 | 0.77(0.31–1.87) | |
AA+GA | 613(100) | 599(99.5) | – | – | 558(98.4) | 529(98.0) | ||||