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Table 4 Haplotype analyses in the Tibetan population

From: 2′-5′-Oligoadenylate synthetase 1 polymorphisms are associated with tuberculosis: a case-control study

 

Tibetan population

Han population

Haplotype

Cases, n (%)

Controls, n (%)

P

OR

Cases, n (%)

Controls, n (%)

P

OR

AGAA

198 (16.1)

162 (13.5)

0.038

1.27(1.01–1.59)

132(11.4)

113(10.4)

0.454

1.11 (0.85–1.45)

AGGA

53 (4.3)

80 (6.6)

0.018

0.65(0.46–0.93)

74(6.4)

94(8.7)

0.043

0.72(0.53–0.99)

CAAA

690 (56.3)

640 (53.2)

0.035

1.19(1.01–1.40)

538(46.4)

459(42.5)

0.052

1.18(1.00–1.40)

CAAG

54 (4.4)

78 (6.5)

0.034

0.68(0.48–0.97)

150(12.9)

142(13.1)

0.926

0.99(0.77–1.27)

CGAA

75 (6.1)

94 (7.8)

0.153

0.80(0.58–1.09)

60(5.2)

69(6.4)

0.227

0.80(0.56–1.15)

CGGA

121 (9.9)

141 (11.7)

0.207

0.85(0.66–1.10)

190(16.4)

193(17.9)

0.357

0.90(0.72–1.12)

Othera

35 (2.9)

9 (0.7)

 

15(1.4)

11(0.9)

  
  1. CI confidence interval, OR odds ratio
  2. aThose lowest frequency threshold (LFT) < 0.03 were pooled in this part
  3. Bonferroni correction was performed with p ≤ 0.008 (0.05/6) considered significant
  4. For each haplotype, alleles are arranged in order of rs2240190, rs1131454, 10,774,671 and 11,066,453