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Table 2 Correlations between spirometry, histogram characteristics and CT-density scores

From: Automated computed tomographic scoring of lung disease in adults with primary ciliary dyskinesia

 

FEV1

FVC

R

P value

R

P value

Histogram characteristics

- MLD

−0.22

0.084

− 0.31

0.012

- Mode

0.14

0.285

0.11

0.397

- SD

−0.63

< 0.001

− 0.67

< 0.001

- Kurtosis

0.56

< 0.001

0.65

< 0.001

- Skewness

0.60

< 0.001

0.67

< 0.001

CT-density score with fixed thresholds

- (−) 400 HU

−0.51

< 0.001

−0.59

< 0.001

- (−) 500 HU

−0.53

< 0.001

− 0.61

< 0.001

- (−) 600 HU

− 0.54

< 0.001

−0.61

< 0.001

CT-density score with adapted thresholds

- MLD + 2 SD

−0.62

< 0.001

−0.67

< 0.001

- MLD + 1 SD

−0.68

< 0.001

− 0.71

< 0.001

- Mode + 500 HU

− 0.57

< 0.001

−0.64

< 0.001

- Mode + 400 HU

−0.60

< 0.001

− 0.65

< 0.001

- Mode + 300 HU

− 0.64

< 0.001

−0.70

< 0.001

- Mode + 3 SD

−0.54

< 0.001

− 0.62

< 0.001

- Mode + 2 SD

− 0.65

< 0.001

−0.70

< 0.001

- Mode + 1SD

−0.66

< 0.001

− 0.68

< 0.001

  1. Definition of abbreviations: CT computed tomography, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, HU Hounsfield unit, MLD Mean Lung Density, SD Standard Deviation