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Table 5 Frequency and incidence of outcomesa,b among the IPF cohorts during follow-up

From: Characterizing idiopathic pulmonary fibrosis patients using US Medicare-advantage health plan claims data

  Restricted to Patients without the Condition during Baseline
  IPF Cohort
(N= 4,716)
IPF Diagnostic Testing Subgroup
(N= 2,518)
  Total Patients Eligible for Outcome # of Patients with Outcome Person-Years IR 95% CI Total Patients Eligible for Outcome # of Patients with Outcome Person-Years IR 95% CI
Primary Outcomes
Acute Respiratory Worsening of Unknown Cause 4,590 110 5,803 19.0 15.6 - 22.8 2,392 61 2,915 20.9 16.0 - 26.9
Pulmonary Hypertension 4,497 260 5,654 46.0 40.6 - 51.9 2,357 145 2,862 50.7 42.8 - 59.6
Pulmonary Arterial Hypertension 4,706 13 5,976 2.2 1.2 - 3.7 2,513 6 3,062 2.0 0.7 - 4.3
Lung Transplantationc 4,706 6 5,980 1.0 0.4 - 2.2 2,516 3 3,074 1.0 0.2 - 2.9
Lung Cancer 3,959 130 5,003 26.0 21.7 - 30.9 2,025 80 2,431 32.9 26.1 - 41.0
Acute Myocardial Infarctiond 4,591 199 5,784 34.4 29.8 - 39.5 2,440 108 2,950 36.6 30.0 - 44.2
Acute Myocardial Infarctione 4,588 156 5,779 27.0 22.9 - 31.6 2,446 88 2,956 29.8 23.9 - 36.7
All-Cause Mortality 4,716 1,082 5,998 180.4 169.8 - 191.5 2,518 584 3,076 189.9 174.8 - 205.9
Secondary Outcomes
GI Perforation 4,705 30 5,952 5.0 3.4 - 7.2 2,512 15 3,058 4.9 2.7 - 8.1
Chronic Renal Failure/Insufficiency 3,466 633 4,141 152.9 141.2 - 165.2 1,800 315 2,092 150.6 134.4 - 168.2
Hemorrhagic Diathesis or Coagulopathy 4,596 135 5,763 23.4 19.6 - 27.7 2,438 73 2,939 24.8 19.5 - 31.2
Venous Thrombosis 4,412 259 5,454 47.5 41.9 - 53.6 2,328 151 2,755 54.8 46.4 - 64.3
Pulmonary Embolism 4,561 143 5,712 25.0 21.1 - 29.5 2,420 77 2,916 26.4 20.8 - 33.0
Strokef 4,537 187 5,631 33.2 28.6 - 38.3 2,427 96 2,895 33.2 26.9 - 40.5
Strokeg 4,637 129 5,778 22.3 18.6 - 26.5 2,479 64 2,963 21.6 16.6 - 27.6
Cardiac Arrhythmia 3,104 640 3,594 178.1 164.5 - 192.4 1,583 315 1,772 177.8 158.7 - 198.6
Congestive Heart Failure 3,221 641 3,948 162.4 150.0 - 175.4 1,669 322 1,981 162.5 145.3 - 181.3
Ischemic Heart Disease 2,810 494 3,197 154.5 141.2 - 168.8 1,445 249 1,569 158.7 139.6 - 179.7
Arterial Hypertension 1,117 401 1,071 374.3 338.6 - 412.8 577 197 516 382.0 330.5 - 439.2
Neutropenia 4,676 55 5,920 9.3 7.0 - 12.1 2,486 29 3,021 9.6 6.4 - 13.8
Pneumonia 4,280 382 5,294 72.2 65.1 - 79.8 2,232 189 2,670 70.8 61.0 - 81.6
Sepsis 4,471 348 5,610 62.0 55.7 - 68.9 2,368 166 2,873 57.8 49.3 - 67.3
COPD 2,288 607 2,457 247.1 227.8 - 267.5 1,131 298 1,150 259.1 230.5 - 290.2
GERD 3,395 565 3,657 154.5 142.0 - 167.8 1,757 289 1,814 159.3 141.5 - 178.8
Type 2 Diabetes Mellitus 3,183 234 3,947 59.3 51.9 - 67.4 1,672 121 2,003 60.4 50.1 - 72.2
Obstructive sleep apnea 4,333 176 5,329 33.0 28.3 - 38.3 2,294 94 2,703 34.8 28.1 - 42.6
Bronchitis 2,805 697 2,857 243.9 226.2 - 262.7 1,420 340 1,365 249.1 223.3 - 277.0
Upper Respiratory Tract Infection 4,265 337 4,960 67.9 60.9 - 75.6 2,252 181 2,504 72.3 62.1 - 83.6
Pulmonary Rehabilitation 4,640 130 5,773 22.5 18.8 - 26.7 2,466 85 2,934 29.0 23.1 - 35.8
Acute Coronary Syndrome 4,570 138 5,647 24.4 20.5 - 28.9 2,436 73 2,894 25.2 19.8 - 31.7
Angina Pectoris 4,460 151 5,493 27.5 23.3 - 32.2 2,365 81 2,795 29.0 23.0 - 36.0
Bleeding 4,149 550 4,758 115.6 106.1 - 125.7 2,199 274 2,434 112.6 99.7 - 126.7
Major GI Bleeding (Upper) 4,641 89 5,842 15.2 12.2 - 18.7 2,478 47 2,994 15.7 11.5 - 20.9
Major GI Bleeding (Lower) 4,404 311 5,325 58.4 52.1 - 65.3 2,338 165 2,727 60.5 51.6 - 70.5
Hemorrhage of the Rectum or Anus 4,598 129 5,708 22.6 18.9 - 26.9 2,449 65 2,915 22.3 17.2 - 28.4
Blood in Stool 4,589 164 5,663 29.0 24.7 - 33.7 2,456 85 2,920 29.1 23.3 - 36.0
Epistaxis 4,596 144 5,708 25.2 21.3 - 29.7 2,447 70 2,925 23.9 18.7 - 30.2
Hemorrhoids 4,610 114 5,725 19.9 16.4 - 23.9 2,461 57 2,941 19.4 14.7 - 25.1
Hemorrhoidal Bleeding 4,686 31 5,920 5.2 3.6 - 7.4 2,502 16 3,038 5.3 3.0 - 8.6
Intracranial Hemorrhage 4,677 58 5,913 9.8 7.4 - 12.7 2,499 35 3,021 11.6 8.1 - 16.1
Acute Pancreatitis 4,669 37 5,910 6.3 4.4 - 8.6 2,491 14 3,041 4.6 2.5 - 7.7
Hepatic Failure 4,702 22 5,990 3.7 2.3 - 5.6 2,511 11 3,072 3.6 1.8 - 6.4
Acute Renal Failure 4,101 506 5,189 97.5 89.2 - 106.4 2,140 261 2,630 99.2 87.6 - 112.0
Depression (MDD only) 4,141 398 4,964 80.2 72.5 - 88.5 2,203 208 2,531 82.2 71.4 - 94.1
Depression (MDD and other) 4,068 420 4,831 86.9 78.8 - 95.7 2,163 229 2,456 93.3 81.6 - 106.1
  1. Optum Research Database – Medicare Advantage Population
  2. Cohort Entry: 01 January 2008 - 30 September 2014
  3. Abbreviations: IR incidence rate per 1,000 person-years, CI confidence Interval, IPF idiopathic pulmonary fibrosis, COPD chronic obstructive pulmonary disease, GERD, gastroesophageal reflux disease, MDD major depressive disorder;
  4. aThe mean follow-up time was 0.8 years (IPF cohort) and 0.7 years subgroup)
  5. bOccurrence of one outcome did not preclude the occurrence of another, with the exception of all-cause mortality, which would result in censoring all additional follow-up
  6. cFor lung transplantation, patients with unilateral lung transplantation during the baseline period could be "at-risk" to receive another unilateral lung transplantation during the follow-up period; however, double lung transplantations during the baseline would preclude subsequent "at-risk" person-time during the follow-up period
  7. dPatients with 2+ claims with ICD-9 code of 410.x0 or 410.x1, primary position only. Patients with only one claim with these AMI codes but have claims suggestive of death were classified as AMI cases. Claims must be within 7 days of each other and must be from the inpatient or emergency room setting
  8. ePatients with an ICD-9-CM code for AMI (410.x0, 410.x1) in the principal (or primary) diagnosis position on at least one facility claim for hospitalization. Claims from emergency departments were not be included in the case identification as they are likely to lead to misclassification
  9. fICD-9 code 430, 431, 433.x1, or 434.x1, only in the primary or secondary diagnosis position. For patients identified by 430, 431, exclude if the following ICD-9 diagnosis codes are present on the same day: 800.xx-804.xx, 850.xx-854.xx (in any position); or V57.xx (in the primary position)
  10. gICD-9 code 430, 431, 433.x1 or 434.x1, restricted to the primary diagnosis position on at least 1 facility claim for hospitalization