Part A: Single ascending-dose cohorts | |||||||
 | All Placebo (n = 10) | All BITS7201A (n = 31) | Cohort A 30-mg SC (n = 8) | Cohort B 90-mg SC (n = 8) | Cohort C 300-mg SC (n = 8) | Cohort D 300-mg IV (n = 9) | Cohort E 750-mg IV (n = 8) |
Age (years), mean (SD) | 32.9 (10.75) | 29.8 (9.82) | 30.8 (11.41) | 30.1 (10.76) | 33.5 (10.64) | 29.0 (10.59) | 29.5 (8.40) |
Sex, male, n (%), | 5 (50.0) | 16 (51.6) | 4 (50.0) | 4 (50.0) | 4 (50.0) | 3 (33.3) | 6 (75.0) |
Race, n (%) | |||||||
 White | 9 (90.0) | 21 (67.7) | 5 (62.5) | 6 (75.0) | 6 (75.0) | 5 (55.6) | 8 (100) |
 Black or African American | 1 (10.0) | 9 (29.0) | 3 (37.5) | 2 (25.0) | 2 (25.0) | 3 (33.3) | 0 |
 Multiple | 0 | 1 (3.2) | 0 | 0 | 0 | 1 (11.1) | 0 |
Ethnicity, n (%) | |||||||
 Hispanic or Latino | 1 (10.0) | 0 | 0 | 0 | 1 (12.5) | 0 | 0 |
 Height (cm), mean (SD) | 172.5 (7.62) | 169.7 (10.01) | 170.3 (9.21) | 169.8 (11.66) | 169.7 (7.34) | 168.2 (10.48) | 174.2 (9.40) |
 Weight (kg), mean (SD) | 77.9 (18.12) | 78.8 (16.64) | 80.3 (17.74) | 83.3 (19.17) | 75.8 (16.18) | 77.2 (20.58) | 76.5 (11.70) |
 Body mass index (kg/m2), mean (SD) | 26.2 (5.91) | 27.3 (4.98) | 27.6 (5.34) | 28.7 (5.25) | 26.4 (5.92) | 27.1 (5.65) | 25.3 (4.20) |
Part B: Multiple ascending-dose cohorts | |||||||
 | All Placebo (n = 6) | All BITS7201A (n = 20) | Cohort F 150-mg SC (n = 9) | Cohort G 300-mg SC (n = 8) | Cohort H 600-mg SC (n = 8) | Cohort Ia 600-mg SC (n = 1) | |
Age (years), mean (SD) | 32.8 (8.82) | 36.1 (11.00) | 33.0 (10.07) | 38.1 (9.28) | 35.3 (13.16) | 35.0 | |
Sex n (%) | |||||||
 Male | 4 (66.7) | 11 (55.0) | 7 (77.8) | 5 (62.5) | 2 (25.0) | 1 (100) | |
Race n (%) | |||||||
 White | 4 (66.7) | 14 (70.0) | 5 (55.6) | 6 (75.0) | 6 (75.0) | 1 (100) | |
 Black or African American | 2 (33.3) | 5 (25.0) | 3 (33.3) | 2 (25.0) | 2 (25.0) | 0 | |
 Multiple | 0 | 1 (5.0) | 1 (11.1) | 0 | 0 | 0 | |
Ethnicity n (%) | |||||||
 Hispanic or Latino | 1 (16.7) | 1 (5.0) | 1 (11.1) | 1 (12.5) | 0 | 0 | |
 Height (cm), mean (SD) | 169.4 (12.78) | 169.8 (8.02) | 169.8 (9.33) | 174.1 (7.94) | 164.5 (8.56) | 174.0 | |
 Weight (kg), mean (SD) | 84.0 (23.99) | 80.8 (15.34) | 75.8 (14.88) | 89.6 (17.30) | 76.1 (15.15) | 111.0 | |
 Body mass index (kg/m2), mean (SD) | 28.7 (4.48) | 28.0 (4.90) | 26.1 (3.61) | 29.6 (5.24) | 28.0 (4.40) | 36.7 |