Table 1 Demographic and baseline characteristics

All Placebo

(n = 10)

All BITS7201A

(n = 31)

Cohort A 30-mg SC

(n = 8)

Cohort B 90-mg SC

(n = 8)

Cohort C 300-mg SC

(n = 8)

Cohort D 300-mg IV

(n = 9)

Cohort E 750-mg

IV (n = 8)

Age (years), mean (SD)

32.9 (10.75)

29.8 (9.82)

30.8 (11.41)

30.1 (10.76)

33.5 (10.64)

29.0 (10.59)

29.5 (8.40)

Sex, male, n (%),

5 (50.0)

16 (51.6)

4 (50.0)

4 (50.0)

4 (50.0)

3 (33.3)

6 (75.0)

 White

9 (90.0)

21 (67.7)

5 (62.5)

6 (75.0)

6 (75.0)

5 (55.6)

8 (100)

 Black or African American

1 (10.0)

9 (29.0)

3 (37.5)

2 (25.0)

2 (25.0)

3 (33.3)

0

 Multiple

0

1 (3.2)

0

0

0

1 (11.1)

0

 Hispanic or Latino

1 (10.0)

0

0

0

1 (12.5)

0

0

 Height (cm), mean (SD)

172.5 (7.62)

169.7 (10.01)

170.3 (9.21)

169.8 (11.66)

169.7 (7.34)

168.2 (10.48)

174.2 (9.40)

 Weight (kg), mean (SD)

77.9 (18.12)

78.8 (16.64)

80.3 (17.74)

83.3 (19.17)

75.8 (16.18)

77.2 (20.58)

76.5 (11.70)

 Body mass index (kg/m²), mean (SD)

26.2 (5.91)

27.3 (4.98)

27.6 (5.34)

28.7 (5.25)

26.4 (5.92)

27.1 (5.65)

25.3 (4.20)

All Placebo (n = 6)

All BITS7201A (n = 20)

Cohort F 150-mg SC (n = 9)

Cohort G 300-mg SC (n = 8)

Cohort I^a 600-mg SC (n = 1)

Age (years), mean (SD)

32.8 (8.82)

36.1 (11.00)

33.0 (10.07)

38.1 (9.28)

35.0

 Male

4 (66.7)

11 (55.0)

7 (77.8)

5 (62.5)

1 (100)

 White

4 (66.7)

14 (70.0)

5 (55.6)

6 (75.0)

1 (100)

 Black or African American

2 (33.3)

5 (25.0)

3 (33.3)

2 (25.0)

0

 Multiple

0

1 (5.0)

1 (11.1)

0

0

 Hispanic or Latino

1 (16.7)

1 (5.0)

1 (11.1)

1 (12.5)

0

 Height (cm), mean (SD)

169.4 (12.78)

169.8 (8.02)

169.8 (9.33)

174.1 (7.94)

174.0

 Weight (kg), mean (SD)

84.0 (23.99)

80.8 (15.34)

75.8 (14.88)

89.6 (17.30)

111.0

 Body mass index (kg/m²), mean (SD)

28.7 (4.48)

28.0 (4.90)

26.1 (3.61)

29.6 (5.24)

36.7