Table 2 Annual declines in FEV1 (dFEV1) in tertiles according to relevant covariates at baseline
Entire group n = 62 | dFEV1, ml/year | P-value | |||
|---|---|---|---|---|---|
< 25 n = 20 | 25–38 n = 19 | > 38 n = 23 | |||
Demographic data | |||||
Male, n (%) | 35 (56,5) | 9 (45) | 10 (53) | 16 (70) | 0.25 |
Age, years, mean (SD) | 55.6 (9.5) | 54.5 (9.6) | 56.4 (9.4) | 55.7 (9.6) | 0.80 |
Height, m, mean (SD) | 1.75 (0.1) | 1.72 (0.1) | 1.77 (0.1) | 1.76 (0.1) | 0.36 |
BMI, kg/m2, mean (SD) | 26.5 (4.0) | 26.0 (3.4) | 26.8 (4.8) | 26.9 (3.8) | 0.78 |
Smoking history | |||||
Pack-years, mean (SD) | 9.9 (14.4) | 10.7 (14.4) | 12.6 (15.8) | 6.8 (12.2) | 0.42 |
Current smoker, n (%) | 10 (16) | 4 (20) | 4 (21) | 2 (9) | 0.49 |
Former smoker, n (%) | 18 (29) | 5 (25) | 7 (37) | 6 (26) | 0.73 |
Never smoker, n (%) | 32 (52) | 10 (50) | 8 (42) | 14 (61) | 0.39 |
Unknown, n (%) | 2 (3) | 1 (5) | 0 (0) | 1 (4) | 0.63 |
Lung function data, mean (SD) | |||||
dFEV1, ml/year | 32.9 (26.3) | 4.3 (16.6) | 33.0 (3.8) | 62.5 (14.5) | – |
FEV1, l, mean (SD) | 3.27 (1.0) | 3.1 (1.0) | 3.2 (1.0) | 3.5 (0.9) | 0.47 |
FEV, % of predicted | 102 (15) | 100 (14) | 98 (17) | 104 (13) | 0.38 |
FVC, l | 4.3 (1.2) | 4.1 (1.3) | 4.3 (1.3) | 4.6 (1.1) | 0.49 |
FVC, % of predicted | 110 (14) | 109 (16) | 107 (17) | 111 (11) | 0.67 |
FEV1/FVC, % | 76 (6) | 76 (6) | 76 (7) | 77 (6) | 0.94 |
WBCs × 109/l, GM (GSD) | |||||
Total number | 5.9 (1.7) | 6.3 (1.3) | 5.6 (1.8) | 5.8 (1.8) | 0.53 |
Neutrophils | 3.4 (1.3) | 3.7 (1.1) | 3.2 (1.4) | 3.3 (1.3) | 0.43 |
Monocytes | 0.4 (0.1) | 0.4 (0.1) | 0.4 (0.1) | 0 (0.2) | 0.35 |
Lymphocytes | 1.8 (0.6) | 1.8 (0.5) | 1.8 (0.6) | 1.8 (0.7) | 1.00 |
Eosinophils | 0.0 (0.1) | 0.1 (0.1) | 0 (0.1) | 0.1 (0.1) | 0.13 |
Sputum cells, % | |||||
Macrophages | 36 (17) | 38 (20) | 31 (18) | 44 (12) | 0.06 |
Neutrophils | 61 (18) | 60 (20) | 67 (18) | 53 (12) | 0.05 |
Lymphocytes | 2 (1) | 2 (1) | 2 (1) | 2 (1) | 0.63 |
Eosinophils | 1 (2) | 1 (1) | 1 (1) | 2 (4) | 0.41 |