Table 2 Inhaled pharmacological wash-out
Inhaled medication used before wash-out | Inhaled medication used during wash-out | Duration of wash-out |
|---|---|---|
Tiotropium (18μg once q.d) | Maintain the original regimen | No washout, go directly into randomization |
Budesonide/formoterol (160μg/4.5μg once or twice b.i.d) | ||
Tiotropium (18μg once q.d) + budesonide/formoterol (160μg/4.5μg once or twice b.i.d) | ||
No use of inhaled medication | Tiotropium (18μg once q.d) | Four weeks |
Anticholinergic agents except tiotropium | ||
Inhaled corticosteroids only | Tiotropium (18μg once q.d) + budesonide/formoterol (160μg/4.5μg once or twice b.i.d) | |
Inhaled β2-agonist only | ||
ICS/LABA except budesonide/formoterol | ||
LAMA+ICS/LABA except Tiotropium + budesonide/formoterol |