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Table 2 Inhaled pharmacological wash-out

From: A prospective study of salvational intervention with ICS/LABA for reducing chronic obstructive pulmonary disease exacerbation under severe air pollution (SIRCAP) in Beijing: protocol of a multi-center randomized controlled trial

Inhaled medication used before wash-out Inhaled medication used during wash-out Duration of wash-out
Tiotropium (18μg once q.d) Maintain the original regimen No washout, go directly into randomization
Budesonide/formoterol (160μg/4.5μg once or twice b.i.d)
Tiotropium (18μg once q.d) + budesonide/formoterol (160μg/4.5μg once or twice b.i.d)
No use of inhaled medication Tiotropium (18μg once q.d) Four weeks
Anticholinergic agents except tiotropium
Inhaled corticosteroids only Tiotropium (18μg once q.d) + budesonide/formoterol (160μg/4.5μg once or twice b.i.d)
Inhaled β2-agonist only
ICS/LABA except budesonide/formoterol
LAMA+ICS/LABA except Tiotropium + budesonide/formoterol