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Table 6 Differences in terms of safety outcome and diagnostic yield between different sampling strategies

From: Diagnostic yield and risk/benefit analysis of trans-bronchial lung cryobiopsy in diffuse parenchymal lung diseases: a large cohort of 699 patients

 

1 site

2 sites

Fisher’s exact test

Pneumothorax

64/420 (15.2%)

66/268 (24.6%)

p 0,002

Bleeding

51/418 (12.2%)

32/266 (12.0%)

p 0,947

Pathological diagnosis

358/422 (84.8%)

247/267 (92.5%)

p 0,001

Multidisciplinary diagnosis

373/422 (88.4%)

248/267 (92.9%)

p 0,043

 

1 lobe

Different lobes

Fisher’s exact test

Pneumothorax

36/166 (21.7%)

30/102 (29.4%)

p 0,083

Bleeding

19/166 (11.4%)

13/100 (13%)

p 0,7112

Pathological diagnosis

155/166 (93.4%)

92/101 (91.1%)

p 0,5081

Multidisciplinary diagnosis

156/166 (93.9%)

92/101 (91.1%)

p 0,3967

 

Upper lobes (a)

Lower lobes (a)

Fisher’s exact test

Pneumothorax

4/80 (5%)

57/298 (19.1%)

p 0,00004

Bleeding

5/78 (6.4%)

42/298 (14.1%)

p 0,0270

 

1.9 probe

2.4 probe

Fisher’s exact test

Pneumothorax

2/73 (2.7%)

130/613 (21.2%)

p < 0,0001

Bleeding

8/73 (10.9%)

78/611 (12.8%)

p 0,6460

Pathological diagnosis

62/73 (84.9%)

541/615 (87.9%)

p 0,4936

Multidisciplinary diagnosis

62/63 (84.9%)

557/615 (90.6%)

p 0,2014

  1. (a) Cases in which biopsies were performed in the middle lobe or lingula or when it was not possible to establish the exact site of the biopsy were excluded