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Table 1 Clinical characteristics of the training and validation group

From: Development and validation of a simple-to-use clinical nomogram for predicting obstructive sleep apnea

Characteristics

Training group (n = 2913)

 

Validation group (n = 1249)

 

Demographics

non-OSA (n = 537)

OSA (n = 2376)

P value

non-OSA (n = 238)

OSA (n = 1011)

P value

Age, years

37(30~47)

42(34~53)

< 0.001

37(30~47)

43(34~53)

< 0.001

Male (%)

58.8

84.7

< 0.001

61.8

84.6

< 0.001

BMI, Kg/m2

23.71(21.79~25.52)

27.04(24.77~29.39)

< 0.001

23.28(21.29~25.71)

26.45(24.45~29.06)

< 0.001

NC, cm

36(34~39)

40(38~42)

< 0.001

36.75(34~38)

40(38~42)

< 0.001

WC, cm

86(80~92)

97(91~103)

< 0.001

85 (79~92)

96 (90~103)

< 0.001

HC, cm

96(92~100)

102(97~106)

< 0.001

96(92~100)

101(97~106)

< 0.001

Glucose (mmol/L)

5.01(4.65~5.31)

5.31(4.97~5.82)

< 0.001

4.97(4.65~5.30)

5.28(4.94~5.77)

< 0.001

Insulin (uU/ml)

7.35(5.23~10.49)

11.65(7.96~16.90)

< 0.001

7.11(4.92~9.83)

10.18(6.75~15.78)

< 0.001

SBP, mmHg

120(110~126)

125(117~135)

< 0.001

120(111~126)

125(116~135)

< 0.001

DBP, mmHg

77(70~81)

80(74~88)

< 0.001

77(70~82)

80(73~87)

< 0.001

TC

4.36(3.76~4.91)

4.75(4.20~5.35)

< 0.001

4.30(3.75~4.95)

4.78(4.19~5.40)

< 0.001

TG

1.10(0.75~1.58)

1.63(1.16~2.38)

< 0.001

1.12(0.72~1.62)

1.62(1.12~2.35)

< 0.001

HDL-C

1.10(0.96~1.285)

1.02(0.90~1.18)

< 0.001

1.10(0.96~1.29)

1.03(0.90~1.18)

< 0.001

LDL-C

2.63(2.14~3.14)

3.02(2.53~3.53)

< 0.001

2.63(2.18~3.23)

3.02(2.50~3.59)

< 0.001

ApoA-I

1.10(0.96~1.25)

1.05(0.95~1.19)

< 0.001

1.07(0.96~1.22)

1.07(0.96~1.19)

0.409

ApoB

0.74(0.63~0.86)

0.84(0.74~0.96)

< 0.001

0.72(0.63~0.87)

0.84(0.74~0.96)

< 0.001

ApoE

3.89(3.22~4.69)

4.32(3.55~5.46)

< 0.001

3.81(3.10~4.78)

4.34(3.58~5.38)

< 0.001

Lpa

7.88(4.29~16.85)

7.4(3.8~15.18)

0.037

7.70(4.25~16.35)

7.7(3.8~15.3)

0.532

AHI

1.4(0.5~2.9)

40.9(18.7~62.1)

< 0.001

1.85(0.60~3.40)

38.9(17.8~61.2)

< 0.001

Mean SaO2

97(96~97)

94(92~95.8)

< 0.001

97(96~97.45)

94(92~95.7)

< 0.001

Minimum SaO2

94(91~96)

78(68~85)

< 0.001

94(91~96)

79(68~85)

< 0.001

ODI

1.6 (0.6~3.5)

41.2(18.13~63.5)

< 0.001

1.8(0.7~3.5)

38.2(18.2~63)

< 0.001

MAI

11.8(7.6~19.1)

25(13.2~43.78)

< 0.001

12.8(8.05~20.43)

25.7(13.8~45.2)

< 0.001

  1. The data are presented as means and standard deviation; skewed data are presented as the median (IQR), and categorical data as the number (percentage)
  2. Differences in the baseline characteristics among the two groups were examined using independent samples t test or Mann–Whitney U test for continuous variables and chi-square test or Fisher’s exact test for categorical variables
  3. OSA obstructive sleep apnea, BMI body mass index, NC neck circumference, WC waist circumference, HC hip circumference, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein; cholesterol, ApoA-I apolipoprotein A-I, ApoB apolipoprotein B, AHI apnoea–hypopnea index, SaO2 oxygen saturation, ODI oxygen desaturation index, MAI micro-arousal index