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Table 2 Multivariate models predicting ΔBorg in AMP and adenosine provocation

From: Associations of AMP and adenosine induced dyspnea sensation to large and small airways dysfunction in asthma

 

AMP

 

A.

B.

 

B (p-value)

B (p-value)

Gender

0.25 (0.78)

0.55 (0.62)

Smoking status

−0.11 (0.90)

− 0.23 (0.81)

Δ FEV1 (L)

−0.97 (0.62)

− 0.74 (0.72)

Δ FEF50 (Ls− 1)

0.50 (0.54)

0.60 (0.48)

Δ R20 (kPa sL−1)

−2.00 (0.76)

− 1.01 (0.88)

Δ X5 (kPa sL−1)

−0.64 (0.67)

− 0.69 (0.65)

Δ LCI5%

 

0.22 (0.65)

 

Adenosine

 

A.

B.

 

B (p-value)

B (p-value)

Gender

−0.83 (0.37)

−0.81 (0.37)

Smoking status

0.32 (0.65)

0.45 (0.51)

Δ FEV1 (L)

1.50 (0.43)

0.98 (0.60)

Δ FEF25–75 (Ls−1)

−2.18 (0.04)

− 1.82 (0.09)

Δ R20 (kPa sL− 1)

−8.28 (0.11)

−6.53 (0.20)

Δ R5-R20 (kPa sL− 1)

2.61 (0.27)

3.20 (0.18)

Δ Scond

 

14.56 (0.16)

  1. A. The models based on all subjects and B. the models incorporating multiple breath nitrogen washout (MBNW). Δ = change (post-pre); FEV1 = forced expiratory volume in the first second; FEF50 = forced expiratory flow at 50% of FVC; FEF25–75 = forced expiratory flow at 25 to 75% of FVC; R20 = resistance to 20 Hz; X5 = reactance to 5 Hz; R5-R20 = difference in resistance to 5 Hz and 20 Hz; LCI5% = lung clearance index at 5%; Scons = ventilation heterogeneity of the conducting airways