Fig. 5
From: TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis
AAL(s) treated wild type mice and Tnfsf10−/− mice were protected from bleomycin-induced collagen deposition and apoptosis. Collagen deposition in Masson’s trichrome stained lung sections (a). Images at 200x magnification of representative sections from Masson’s trichrome for (b) Wild Type saline and (c) bleomycin treated (d) wildtype bleomycin treated with AAL(s), (e) TRAIL−/− bleomycin treated and (f) TRAIL −/− saline. Apoptosis in terms of the percentage of TUNEL positive cells in lung sections (g), which peaked at one day post bleomycin but was still significantly elevated after day 21(h). n = 6, * p < 0.05