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Fig. 4 | BMC Pulmonary Medicine

Fig. 4

From: Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K/Akt/mTOR and hedgehog signalling via increasing miR-193a expression

Fig. 4

Effect of ligustrazin on Akt, Beclin1mTOR, and LC3-II mRNA expression levels during PQ-induced pulmonary fibrosis. Mice were treated with ligustrazin and PQ for 14 d. a Relative mRNA levels of mTOR, Akt, LC3-II, and Beclin1 were determined with qRT-PCR. b-f Relative levels of p-Akt, LC3-II, p-mTOR, and Beclin1 proteins were determined by western blotting. Bars indicate the mean ± SD. **p < 0.01, *p < 0.05 vs. controls; #p < 0.05 vs. the model group

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