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Table 1 Demographics and bronchoalveolar lavage fluid characteristics of patients with diffuse lung diseases (DLD) by diagnosis

From: NK and NKT cells in the diagnosis of diffuse lung diseases presenting with a lymphocytic alveolitis

 

All patients (n = 202)

Sarcoidosis (n = 106)

Hypersensitivity pneumonitis (n = 53)

Other DLDs

All (n = 43)

Organising pneumonia (n = 10)

Pulmonary involvement in connective tissue diseases (n = 25)

Idiopathic pulmonary fibrosis (n = 8)

Age, years (mean ± SD)*

46.8 ± 15.8

38.7 ± 11.2

51.3 ± 16.3

61.5 ± 12.0

57.9 ± 11.4

59.1 ± 11.3

73.4 ± 8.2

Gender (female/male)

118/84

60/46

32/21

26/17

5/5

20/5

1/7

Smoking status (no/yes)†† a

151/48

78/26

44/9

29/13

7/2

20/5

2/6

Total cell count b, ×105cells/mL (median, P25-P75)**

1.7 (0.9–3.3)

1.6 (0.8–2.8)

2.8 (1.2–6.1)

1.4 (0.8–2.4)

1.6 (0.7–2.4)

1.2 (0.8–2.5)

1.5 (1.0–3.6)

Neutrophils b,% (median, P25-P75)*

2.8 (1.2–5.8)

1.6 (1.0–3.0)

4.8 (2.7–8.2)

5.8 (2.4–9.8)

8.7 (5.0–9.9)

3.6 (1.5–9.8)

7.2 (4.7–16.5)

Eosinophils b, % (median, P25-P75)*

0.6 (0.2–2.0)

0.4 (0.1–1.0)

1.6 (0.5–3.7)

0.8 (0.2–2.8)

1.6 (0.4–6.5)

0.4 (0.0–1.5)

2.5 (1.1–8.7)

Alveolar macrophages b, % (median, P25-P75)*

49.2 (34.6–65.2)

56.0 (37.6–68.7)

32.4 (22.9–49.0)

55.2 (42.0–66.4)

44.1 (28.1–58.2)

55.8 (43.3–68.2)

58.6 (44.7–65.3)

Lymphocytes b, % (median, P25-P75)*

41.8 (28.0–57.4)

39.9 (23.9–56.6)

53.2 (41.0–69.1)

31.2 (23.8–43.8)

42.3 (27.6–57.1)

30.0 (23.7–44.8)

26.8 (20.1–33.0)

  1. SD standard-deviation, P percentile
  2. *p < 0.001 for the comparison between sarcoidosis, hypersensitivity pneumonitis and all other DLD (Kruskal-Wallis test); p = 0.302 for the comparison between sarcoidosis, hypersensitivity pneumonitis and all other DLD (chi-square test); ††p = 0.274 for the comparison between sarcoidosis, hypersensitivity pneumonitis and all other DLD (chi-square test); **p = 0.001 for comparison between sarcoidosis, hypersensitivity pneumonitis and all other DLD (Kruskal-Wallis test)
  3. aNo information for 3 patients – 2 with sarcoidosis and 1 with organizing pneumonia
  4. bNumbers obtained from microscopic counting