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Table 3 Results of univariate and multivariate analyses with hypersensitivity pneumonitis versus other lung diseases

From: NK and NKT cells in the diagnosis of diffuse lung diseases presenting with a lymphocytic alveolitis

Lymphocyte populations

Crude OR (95%CI)

P value

Adjusted OR (95%CI)

P value

A. Hypersensitivity pneumonitis versus other diffuse lung diseases (sarcoidosis and other diffuse lung diseases)

 CD8+ (%)

1.02 (1.01–1.04)

0.004

1.03 (1.01–1.04)a

0.003

 NK (%)

1.28 (1.14–1.45)

< 0.001

1.29 (1.14–1.46)b

< 0.001

 NKT (%)

1.03 (0.99–1.06)

0.184

1.02 (0.98–1.06)c

0.386

 CD8+ (absolute count)g

1.02 (1.01–1.03)

< 0.001

1.01 (1.00–1.02)d

0.070

 NK (absolute count)g

1.25 (1.12–1.39)

< 0.001

1.15 (1.03–1.29)e

< 0.001

 NKT (absolute count)g

1.08 (1.03–1.13)

0.002

1.02 (0.99–1.06)f

0.241

B. Hypersensitivity pneumonitis versus sarcoidosis

 CD8+ (%)

1.04 (1.03–1.06)

< 0.001

1.05 (1.03–1.07)a

< 0.001

 NK (%)

1.27 (1.11–1.45)

< 0.001

1.29 (1.12–1.49)b

< 0.001

 NKT (%)

1.02 (0.98–1.06)

0.282

1.01 (0.97–1.05)c

0.725

 CD8+ (absolute count)g

1.02 (1.01–1.03)

< 0.001

1.02 (1.00–1.03)d

0.025

 NK (absolute count)g

1.21 (1.09–1.35)

< 0.001

1.12 (1.00–1.25)e

0.055

 NKT (absolute count)g

1.07 (1.02–1.12)

0.007

1.02 (0.98–1.05)f

0.410

C. Sarcoidosis versus all other diffuse lung diseases (hypersensitivity pneumonitis and other diffuse lung diseases)

 CD8+ (%)

0.95 (0.94–0.97)

< 0.001

0.95 (0.93–0.97)a

< 0.001

 NK (%)

0.87 (0.78–0.97)

0.014

0.85 (0.75–0.96)b

0.010

 NKT (%)

0.99 (0.96–1.03)

0.574

1.00 (0.96–1.04)c

0.938

 CD8+ (absolute count)g

0.98 (0.97–0.99)

< 0.001

0.98 (0.97–0.99)d

0.005

 NK (absolute count)g

0.90 (0.83–0.97)

0.007

0.96 (0.90–1.03)e

0.239

 NKT (absolute count)g

0.97 (0.93–1.00)

0.041

0.99 (0.97–1.03)f

0.993

  1. Results of univariate and multivariate analyses with hypersensitivity pneumonitis (versus the other diffuse lung diseases – 3A; and versus sarcoidosis only – 3B) and sarcoidosis (versus the other diffuse lung diseases – 3C) as dependent variables. Absolute numbers and percentages of CD8+, NK, and NKT cells in the bronchoalveolar lavage fluid were assessed as independent variables
  2. CI confidence interval, NK natural killer, OR odds ratio
  3. aadjusted for percentage of NK and NKT cells
  4. badjusted for percentage of CD8+ and NKT cells
  5. cadjusted for percentage of CD8+ and NK cells
  6. dadjusted for absolute number of NK and NKT cells
  7. eadjusted for absolute number of CD8+ and NKT cells
  8. fadjusted for absolute number of CD8+ and NK cells
  9. gOdds ratio and confidence intervals expressed in number of cells/μL