Table 5 Diagnosis of hypersensitivity pneumonitis versus other diffuse lung diseases (sarcoidosis + other diffuse lung diseases)
From: NK and NKT cells in the diagnosis of diffuse lung diseases presenting with a lymphocytic alveolitis
Percentage of natural killer cells | Percentage of CD8+ cells | ||||
Cut-off | Sn - % (95%CI) | Sp - % (95%CI) | Cut-off | Sn - % (95%CI) | Sp - % (95%CI) |
0.5 | 94 (91–97) | 21 (15–27) | 15 | 83 (78–88) | 32 (26–38) |
1.0 | 84 (79–89) | 37 (30–44) | 20 | 78 (72–84) | 45 (38–52) |
1.5 | 73 (67–79) | 57 (50–64) | 25 | 65 (58–72) | 56 (49–63) |
2.0 | 55 (48–62) | 73 (67–79) | 30 | 61 (54–68) | 63 (56–70) |
2.5 | 45 (38–52) | 81 (76–86) | 35 | 57 (50–64) | 67 (61–74) |
3.0 | 41 (34–48) | 86 (81–91) | 40 | 49 (42–56) | 72 (66–78) |
3.5 | 37 (30–44) | 88 (84–92) | 45 | 41 (34–48) | 77 (71–83) |
4.0 | 33 (27–40) | 92 (88–96) | 50 | 35 (28–42) | 81 (76–86) |
4.5 | 31 (25–37) | 93 (89–97) | 55 | 29 (23–35) | 86 (81–91) |
5.0 | 27 (21–33) | 93 (89–97) | 60 | 18 (13–23) | 87 (82–92) |
Absolute number of natural killer cells/mL | Absolute number of CD8+ cells/mL | ||||
Cut-off | Sn - % (95%CI) | Sp - % (95%CI) | Cut-off | Sn - % (95%CI) | Sp - % (95%CI) |
500 | 88 (84–92) | 50 (43–57) | 15,000 | 61 (54–68) | 63 (56–70) |
1000 | 65 (58–72) | 65 (58–72) | 20,000 | 55 (48–62) | 73 (67–79) |
1500 | 59 (52–66) | 74 (68–80) | 25,000 | 53 (46–60) | 78 (72–84) |
2000 | 53 (46–60) | 78 (72–84) | 30,000 | 49 (42–56) | 79 (73–85) |
2500 | 49 (42–56) | 86 (81–91) | 35,000 | 47 (40–54) | 84 (79–89) |
3000 | 47 (40–54) | 91 (87–95) | 40,000 | 47 (40–54) | 87 (82–92) |
3500 | 47 (40–54) | 92 (88–96) | 45,000 | 45 (38–52) | 89 (85–93) |
4000 | 43 (36–50) | 94 (91–97) | 50,000 | 41 (34–48) | 89 (85–93) |
4500 | 43 (36–50) | 94 (91–97) | 55,000 | 33 (27–40) | 91 (87–95) |
5000 | 41 (34–48) | 95 (92–98) | 60,000 | 33 (27–40) | 93 (89–97) |