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Table 3 Particle diameters and span of Man+Leu and mannitol emitted from a large-sized nasal cannula

From: Aerosol drug delivery to the lungs during nasal high flow therapy: an in vitro study

DFR

(L/min)

D10

(μm)

D50

(μm)

D90

(μm)

Span

Man+Leu

20

1.31 ± 0.04

3.23 ± 0.24

10.6 ± 2.11

2.86 ± 0.44

25

1.23 ± 0.03

3.28 ± 0.17

12.7 ± 2.96

3.48 ± 0.83

30

1.26 ± 0.08

3.85 ± 0.14

14.8 ± 1.48

3.51 ± 0.28

Mannitol

20

1.95 ± 0.13

7.17 ± 1.43

62.1 ± 21.3

8.67 ± 3.29

25

1.69 ± 0.10

4.33 ± 0.33*

29.5 ± 7.03

6.36 ± 1.24

30

1.69 ± 0.08*

4.45 ± 0.35*

27.3 ± 5.63*

5.74 ± 1.04

  1. The dose in all experiments was 40 ± 4 mg powder. Each value represents the mean ± SD (n = 3). D10, D50, and D90 are the particle diameters at 10, 50 and 90% of the cumulative particle size, respectively. Significant differences between DFR 20 and 25 L/min or 30 L/min are marked with an asterisk (* p < 0.05)
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BMC Pulmonary Medicine

ISSN: 1471-2466

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