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Table 4 Aerosol performance of Man+Leu at different dispersion and inspiratory flow rates

From: Aerosol drug delivery to the lungs during nasal high flow therapy: an in vitro study

Dispersion flow rate

(L/min)

Inspiratory flow rate

(L/min)

Replica deposition

(% of loaded dose)

NGI deposition

(% of loaded dose)

FPF (% of loaded dose)

20

20

13.28 ± 2.08

24.05 ± 0.17

23.04 ± 0.21

30

19.09 ± 0.59

26.51 ± 0.90

25.64 ± 0.91

40

14.59 ± 1.30

24.14 ± 1.02

23.68 ± 0.99

25

25

17.40 ± 0.78

27.76 ± 1.08

27.45 ± 0.99

40

18.76 ± 1.91

32.32 ± 0.47

32.15 ± 0.47

30

30

15.06 ± 0.74

21.72 ± 0.74

21.03 ± 0.85

40

20.11 ± 2.14

27.16 ± 0.79

26.60 ± 0.71

  1. The loaded dose in all experiments was 40 ± 4 mg powder. Data are represented as the mean ± SEM (n = 3)