Table 2 Table showing the number of SNPs with a p-value below the mentioned threshold for both FEV1/FVC < 70% and < LLN analysis and the overlap
Threshold | Never-smokers | Ever-smokers (> 5 py) | Overlap never- and ever-smokers | |||||
|---|---|---|---|---|---|---|---|---|
70% | LLN | Overlap | 70% | LLN | Overlap | 70% | LLN | |
Discovery analysis (LifeLines) | ||||||||
 < 0.05 | 11,377 | 11,475 | 4755 (26%) | 12,114 | 12,366 | 5445 (29%) | 625 (2.7%) | 616 (2.7%) |
 <0.01 | 2232 | 2197 | 673 (18%) | 2522 | 2493 | 824 (20%) | 23 (0.5%) | 21 (0.4%) |
 < 10−3 | 222 | 233 | 54 (13%) | 246 | 266 | 76 (17%) | 1 (0.2%) | 0 |
 < 10− 4 | 31 | 27 | 2 (4%) | 21 | 29 | 3 (6%) | 0 | 0 |
 < 10−5 | 4 | 4 | 0 | 3 | 2 | 1 (25%) | 0 | 0 |
 < 10− 6 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
 <Bonferroni* | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Replication analysis (Vlagtwedde-Vlaardingen study) | ||||||||
 <0.05 | 10,702 | 10,295 | 4026 (24%) | 12,592 | 12,571 | 4976 (25%) | 487 (2.1%) | 488 (2.2%) |
 <0.01 | 1857 | 1807 | 544 (17%) | 2567 | 2609 | 754 (17%) | 17 (0.4%) | 12 (0.3%) |
 < 10−3 | 164 | 174 | 38 (13%) | 223 | 262 | 41 (9%) | 0 | 0 |
 < 10−4 | 18 | 19 | 6 (19%) | 12 | 21 | 0 | 0 | 0 |
 < 10−5 | 7 | 3 | 2 (25%) | 0 | 0 | 0 | 0 | 0 |
 < 10−6 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
 <Bonferroni* | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |