| Discovery analysis | SNP validation meta-analysis | Direction of effect in the independent cohortsa | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | Chr | A1 | MAF | Gene | Test | OR | SE | P | OR | SE | P | I2 | |
Never-smokers |  | (n = 5070) | (n = 1966) | ||||||||||
 rs7519348 | 1 | A | 33% | NFYC (intronic) | <70% | 1.36 | 0.07 | 4.92 × 10−6 | 1.21 | 0.11 | 0.07 | 0.0 | ++++ 0 |
<LLN | 1.37 | 0.07 | 2.27 × 10−5 | 1.40 | 0.16 | 0.03 | 0.0 | +++++ | |||||
 rs6913003 | 6 | T | 4% | FABP7 (intronic) | < 70% | 1.90 | 0.13 | 8.99 × 10−7 | 1.48 | 0.22 | 0.08 | 0.0 | +++++ |
<LLN | 1.83 | 0.14 | 1.83 × 10−5 | 1.72 | 0.31 | 0.08 | 0.0 | +++++ | |||||
Ever-smokers |  | (n = 4855) | (n = 3134) | ||||||||||
 rs13118083 | 4 | A | 45% | HHIP (342 kb 5′) | <70% | 1.23 | 0.05 | 4.36 × 10−5 | 0.97 | 0.07 | 0.60 | 17.0 | + 0 − − + |
<LLN | 1.26 | 0.05 | 2.27 × 10−5 | 1.05 | 0.08 | 0.57 | 46.7 | ++ 0 − + | |||||
 rs7074210 | 10 | G | 18% | ST8SIA6 (62 kb 5′) | <70% | 1.35 | 0.06 | 3.08 × 10−6 | 1.05 | 0.08 | 0.57 | 64.7 | + − +++ |
<LLN | 1.33 | 0.07 | 3.23 × 10−5 | 0.99 | 0.10 | 0.95 | 64.5 | + − + − + | |||||
 rs4930390 | 11 | G | 24% | C11orf80 (intronic) | <70% | 0.76 | 0.06 | 9.40 × 10−6 | 1.02 | 0.07 | 0.74 | 0.0 | − + 0 – 0 |
<LLN | 0.73 | 0.07 | 6.68 × 10−6 | 1.01 | 0.09 | 0.91 | 10.1 | −++ − − |