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Table 2 Distribution of clinical characteristics, management and concentration of inflammatory biomarkers in children with definite bacterial pneumonia, presumed viral pneumonia and other pneumonia

From: Combination of clinical symptoms and blood biomarkers can improve discrimination between bacterial or viral community-acquired pneumonia in children

Parameter

Definite bacterial pneumonia (N = 30),

A

Presumed viral pneumonia, (N = 118)

B

Other pneumonia, (N = 82)

C

Clinical features

Fever (body temperature ≥ 38.0 °C)

27 (90) λ** μ***

71 (60)

41 (50)

Age-specific Tachypnoea

9 (30)

56 (47) δ**

22 (27)

SpO2% at presentation, median (IQR)

96 (94, 98)

95 (93, 98)

95 (94, 97)

Diagnosis of wheeze at presentation

0 (0)

18 (15)

11 (13)

Diagnosis of crackles/crepitation at presentation

8 (27)

58 (49)

42 (52)

Cough

24 (80)

109 (92)

75 (91)

Rhinorrhea

12 (40)

93 (79) δ*** λ ***

41 (50)

Difficulty in breathing

25 (83)

88 (75)

62 (76)

Vomiting

19 (63)

78 (66)

39 (48)

Body rash

3 (10)

14 (12)

12 (15)

Diarrhea

8 (27)

34 (29)

15 (18)

Poor oral intake

22 (73)

82 (69)

61 (74)

Clinical management

Supplemental O2

16 (53)

65 (55)

35 (43)

Intravenous fluid

22 (73) μ*** λ*

60 (51) δ**

25 (31)

Respiratory support

1 (3)

2 (2)

3 (4)

Supplemental O2 + intravenous fluid

16 (53) μ** λ*

38 (32)

19 (23)

Hospitalization day, median (IQR)

8 (4, 11) μ*** λ***

2 (1, 3)

2 (1, 3)

Blood inflammatory markers

WCC count (×109/L), median (IQR)

16 (11, 21) λ*

11 (8, 18)

12 (8, 18)

CRP (mg/L), median (IQR)

174 (64, 246) λ*** μ***

24 (13, 56)

27 (17, 59)

Absolute neutrophil, (×109/L), median (IQR)

13 (8, 19) λ** μ**

7 (4, 13)

8 (4, 13)

  1. Data are frequency (percentage), unless otherwise mentioned
  2. For comparison, Chi-square test for categorical variables and Wilcoxon-ranksum test for continuous variable was done; *p < 0.05; **p < 0.01; ***p < 0.001
  3. λ Comparison between A and B
  4. μ Comparison between A and C
  5. δ Comparison between B and C