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Table 2 Clinical characteristics of patients with idiopathic pulmonary fibrosis and a main pulmonary artery to aorta diameter ratio ≤ 1 and > 1

From: Prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosis

Clinical factors

mPA/Ao ratio

Univariable analysis

Multivariable analysis

≤1 (n = 272)

> 1 (n = 31)

OR

95% CI

P

OR

95% CI

P

Age, years

67.9 ± 9.1

60.4 ± 10.0

0.92

0.89–0.96

< 0.001

   

Sex, male

215 (79.0%)

19 (61.3%)

2.38

1.09–5.19

0.029

   

BMI, kg/m2 (median, IQR)

22.7 (20.2–24.9)

22.5 (19.1–26.2)

1.01

0.91–1.12

0.848

   

Ever-smoker

194 (71.9%)

17 (54.8%)

0.48

0.22–1.01

0.054

   

Underlying disease

 Hypertension

94 (34.6%)

6 (19.4%)

0.45

0.18–1.15

0.095

   

 Diabetes mellitus

82 (30.1%)

6 (19.4%)

0.56

0.22–1.41

0.215

   

 Pulmonary tuberculosis

41 (15.1%)

2 (6.5%)

0.39

0.09–1.69

0.208

   

 Emphysema

37 (13.7%)

2 (6.5%)

0.44

0.10–1.91

0.270

   

 Ischemic heart disease

28 (10.3%)

1 (3.2%)

0.29

0.04–2.21

0.233

   

 Congestive heart failure

10 (3.7%)

0 (0%)

      

GAP score

3.11 ± 1.24

3.75 ± 1.26

1.57

1.08–2.27

0.018

1.53

0.69–3.40

0.298

6 MW distance, m (median, IQR)

410.0 (322.5–480.0)

232.5 (95.0–555.8)

0.99

0.99–1.00.

0.032

0.99

0.99–1.00

0.190

PFT at diagnosis

 FVC, % predicted, (median, IQR)

75.0 (61.0–86.3)

55.0 (44.5–72.0)

0.95

0.93–0.98

< 0.001

   

 FEV1, % predicted, (median, IQR)

89.5 (73.0–100.0)

64.0 (51.5–81.0)

0.96

0.95–0.98

< 0.001

1.07

0.99–0.15

0.074

 DLCO, %

70.9 ± 23.8

48.4 ± 23.1

0.96

0.94–0.98

< 0.001

   

Echocardiography

 EF, %, (median, IQR)

65.0 (61.0–69.0)

67.0 (64.0–71.0)

1.08

1.01–1.14

0.022

1.09

0.93–1.27

0.285

 RVP, mmHg, (median, IQR)

37.0 (27.8–46.0)

43.0 (33.0–52.5)

1.03

1.01–1.06

0.014

1.04

0.99–1.10

0.113

Chest CT

 mPA diameter, mm, (median, IQR)

27.6 (25.8–29.8)

32.9 (29.8–35.1)

1.38

1.23–1.54

< 0.001

   

 Ascending Ao diameter, mm, (median, IQR)

34.5 (32.0–36.9)

29.8 (27.7–32.8)

0.71

0.62–0.80

< 0.001

   
  1. The data are presented as the number (percentage) unless otherwise indicated. 6MWD, 6-min walking distance
  2. Ao aorta, BMI body mass index, CI confidence interval, DLCO diffusing capacity, EF ejection fraction, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, IQR interquartile range, mPA main pulmonary artery, OR odds ratio, PFT pulmonary function tests, RVP right ventricular pressure
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BMC Pulmonary Medicine

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