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Table 2 Clinical characteristics of patients with idiopathic pulmonary fibrosis and a main pulmonary artery to aorta diameter ratio ≤ 1 and > 1

From: Prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosis

Clinical factors mPA/Ao ratio Univariable analysis Multivariable analysis
≤1 (n = 272) > 1 (n = 31) OR 95% CI P OR 95% CI P
Age, years 67.9 ± 9.1 60.4 ± 10.0 0.92 0.89–0.96 < 0.001    
Sex, male 215 (79.0%) 19 (61.3%) 2.38 1.09–5.19 0.029    
BMI, kg/m2 (median, IQR) 22.7 (20.2–24.9) 22.5 (19.1–26.2) 1.01 0.91–1.12 0.848    
Ever-smoker 194 (71.9%) 17 (54.8%) 0.48 0.22–1.01 0.054    
Underlying disease
 Hypertension 94 (34.6%) 6 (19.4%) 0.45 0.18–1.15 0.095    
 Diabetes mellitus 82 (30.1%) 6 (19.4%) 0.56 0.22–1.41 0.215    
 Pulmonary tuberculosis 41 (15.1%) 2 (6.5%) 0.39 0.09–1.69 0.208    
 Emphysema 37 (13.7%) 2 (6.5%) 0.44 0.10–1.91 0.270    
 Ischemic heart disease 28 (10.3%) 1 (3.2%) 0.29 0.04–2.21 0.233    
 Congestive heart failure 10 (3.7%) 0 (0%)       
GAP score 3.11 ± 1.24 3.75 ± 1.26 1.57 1.08–2.27 0.018 1.53 0.69–3.40 0.298
6 MW distance, m (median, IQR) 410.0 (322.5–480.0) 232.5 (95.0–555.8) 0.99 0.99–1.00. 0.032 0.99 0.99–1.00 0.190
PFT at diagnosis
 FVC, % predicted, (median, IQR) 75.0 (61.0–86.3) 55.0 (44.5–72.0) 0.95 0.93–0.98 < 0.001    
 FEV1, % predicted, (median, IQR) 89.5 (73.0–100.0) 64.0 (51.5–81.0) 0.96 0.95–0.98 < 0.001 1.07 0.99–0.15 0.074
 DLCO, % 70.9 ± 23.8 48.4 ± 23.1 0.96 0.94–0.98 < 0.001    
Echocardiography
 EF, %, (median, IQR) 65.0 (61.0–69.0) 67.0 (64.0–71.0) 1.08 1.01–1.14 0.022 1.09 0.93–1.27 0.285
 RVP, mmHg, (median, IQR) 37.0 (27.8–46.0) 43.0 (33.0–52.5) 1.03 1.01–1.06 0.014 1.04 0.99–1.10 0.113
Chest CT
 mPA diameter, mm, (median, IQR) 27.6 (25.8–29.8) 32.9 (29.8–35.1) 1.38 1.23–1.54 < 0.001    
 Ascending Ao diameter, mm, (median, IQR) 34.5 (32.0–36.9) 29.8 (27.7–32.8) 0.71 0.62–0.80 < 0.001    
  1. The data are presented as the number (percentage) unless otherwise indicated. 6MWD, 6-min walking distance
  2. Ao aorta, BMI body mass index, CI confidence interval, DLCO diffusing capacity, EF ejection fraction, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, IQR interquartile range, mPA main pulmonary artery, OR odds ratio, PFT pulmonary function tests, RVP right ventricular pressure