Anticholinergics aggravate the imbalance of the autonomic nervous system in stable chronic obstructive pulmonary disease

Table 2 CPET variables between COPD with tiotropium and controls

Variables	Patients with tiotropium (n = 24)	Controls (n = 36)	p Value
Peak WR (watt)	83.25 ± 23.19	102.64 ± 31.44	0.011*
Peak VO₂(ml/min)	1155.25 ± 279.91	1409.19 ± 312.94	0.325
Peak VCO₂(ml/min)	1326.63 ± 387.79	1594.31 ± 446.17	0.043*
AT (ml/min)	716.91 ± 286.70	946.44 ± 339.77	0.446
Mean of HRR (beats/min)	16 ± 6	22 ± 8	0.029*
VO₂/WR slope (ml/min/watt)	8.37 ± 1.26	8.92 ± 1.29	0.800
HR/VO₂ slope (beats/ml/min)	47.25 ± 12.71	47.54 ± 12.40	0.622
V_E/VCO₂ slope	29.57 ± 6.71	28.84 ± 7.33	0.923

CPET Cardiopulmonary Exercise Test, COPD chronic obstructive pulmonary disease, WR work rate, VO₂ oxygen uptake, VCO₂ carbon dioxide production, V_E minute ventilation, AT anaerobic threshold, HRR heart rate recovery
*significant difference, P < 0.05

ISSN: 1471-2466