TY - STD TI - Asthma UK. Living on a knife edge. A powerful and moving account of living with serious symptoms of asthma. London: Asthma UK. 2004;1–24. ID - ref1 ER - TY - JOUR AU - Chung, K. F. AU - Wenzel, S. E. AU - Brozek, J. L. AU - Bush, A. AU - Castro, M. AU - Sterk, P. J. PY - 2014 DA - 2014// TI - International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma JO - Eur Respir J VL - 43 UR - https://doi.org/10.1183/09031936.00202013 DO - 10.1183/09031936.00202013 ID - Chung2014 ER - TY - JOUR AU - Chung, K. F. AU - Godard, P. AU - Adelroth, E. AU - Ayres, J. AU - Barnes, N. AU - Barnes, P. PY - 1999 DA - 1999// TI - Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS task force on difficult/therapy-resistant Asthma. European Respiratory Society JO - Eur Respir J VL - 13 ID - Chung1999 ER - TY - JOUR AU - Sastre, J. AU - Fabbri, L. M. AU - Price, D. AU - Wahn, H. U. AU - Bousquet, J. AU - Fish, J. E. PY - 2016 DA - 2016// TI - Insights, attitudes, and perceptions about asthma and its treatment: a multinational survey of patients from Europe and Canada JO - World Allergy Organ J VL - 9 UR - https://doi.org/10.1186/s40413-016-0105-4 DO - 10.1186/s40413-016-0105-4 ID - Sastre2016 ER - TY - JOUR AU - Smith, D. H. AU - Malone, D. C. AU - Lawson, K. A. AU - Okamoto, L. J. AU - Battista, C. AU - Saunders, W. B. PY - 1997 DA - 1997// TI - A national estimate of the economic costs of asthma JO - Am J Respir Crit Care Med VL - 156 UR - https://doi.org/10.1164/ajrccm.156.3.9611072 DO - 10.1164/ajrccm.156.3.9611072 ID - Smith1997 ER - TY - JOUR AU - Barnes, P. J. AU - Jonsson, B. AU - Klim, J. B. PY - 1996 DA - 1996// TI - The costs of asthma JO - Eur Respir J VL - 9 UR - https://doi.org/10.1183/09031936.96.09040636 DO - 10.1183/09031936.96.09040636 ID - Barnes1996 ER - TY - STD TI - England N. Specialised Respiratory Services (adult) – Severe Asthma 2017. Available from: https://www.england.nhs.uk/wp-content/uploads/2017/04/specialised-respiratory-services-adult-severe-asthma.pdf. Accessed 21 May 2019. UR - https://www.england.nhs.uk/wp-content/uploads/2017/04/specialised-respiratory-services-adult-severe-asthma.pdf ID - ref7 ER - TY - JOUR AU - O'Neill, S. AU - Sweeney, J. AU - Patterson, C. C. AU - Menzies-Gow, A. AU - Niven, R. AU - Mansur, A. H. PY - 2015 DA - 2015// TI - The cost of treating severe refractory asthma in the UK: an economic analysis from the British Thoracic Society difficult Asthma registry JO - Thorax. VL - 70 UR - https://doi.org/10.1136/thoraxjnl-2013-204114 DO - 10.1136/thoraxjnl-2013-204114 ID - O'Neill2015 ER - TY - STD TI - GINA. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2018. Available from: https://ginasthma.org/2018-gina/. Accessed 21 May 2019. UR - https://ginasthma.org/2018-gina/ ID - ref9 ER - TY - STD TI - BTS/SIGN. British guideline for the mangment of asthma, SIGN 153, September 2016. Available from: https://www.brit-thoracic.org.uk/quality-improvement/guidelines/asthma/. Accessed 21 May 2019. UR - https://www.brit-thoracic.org.uk/quality-improvement/guidelines/asthma/ ID - ref10 ER - TY - JOUR AU - Barnes, P. J. PY - 2014 DA - 2014// TI - Glucocorticoids JO - Chem Immunol Allergy VL - 100 UR - https://doi.org/10.1159/000359984 DO - 10.1159/000359984 ID - Barnes2014 ER - TY - JOUR AU - Green, R. H. AU - Brightling, C. E. AU - Woltmann, G. AU - Parker, D. AU - Wardlaw, A. J. AU - Pavord, I. D. PY - 2002 DA - 2002// TI - Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids JO - Thorax. VL - 57 UR - https://doi.org/10.1136/thorax.57.10.875 DO - 10.1136/thorax.57.10.875 ID - Green2002 ER - TY - JOUR AU - Fitzpatrick, A. M. AU - Teague, W. G. AU - Meyers, D. A. AU - Peters, S. P. AU - Li, X. AU - Li, H. PY - 2011 DA - 2011// TI - Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute severe Asthma research program JO - J Allergy Clin Immunol VL - 127 UR - https://doi.org/10.1016/j.jaci.2010.11.015 DO - 10.1016/j.jaci.2010.11.015 ID - Fitzpatrick2011 ER - TY - JOUR AU - Just, J. AU - Gouvis-Echraghi, R. AU - Rouve, S. AU - Wanin, S. AU - Moreau, D. AU - Annesi-Maesano, I. PY - 2012 DA - 2012// TI - Two novel, severe asthma phenotypes identified during childhood using a clustering approach JO - Eur Respir J VL - 40 UR - https://doi.org/10.1183/09031936.00123411 DO - 10.1183/09031936.00123411 ID - Just2012 ER - TY - JOUR AU - Kurukulaaratchy, R. J. AU - Zhang, H. AU - Raza, A. AU - Patil, V. AU - Karmaus, W. AU - Ewart, S. PY - 2014 DA - 2014// TI - The diversity of young adult wheeze: a cluster analysis in a longitudinal birth cohort JO - Clin Exp Allergy VL - 44 UR - https://doi.org/10.1111/cea.12306 DO - 10.1111/cea.12306 ID - Kurukulaaratchy2014 ER - TY - JOUR AU - Moore, W. C. AU - Meyers, D. A. AU - Wenzel, S. E. AU - Teague, W. G. AU - Li, H. AU - Li, X. PY - 2010 DA - 2010// TI - Identification of asthma phenotypes using cluster analysis in the severe Asthma research program JO - Am J Respir Crit Care Med VL - 181 UR - https://doi.org/10.1164/rccm.200906-0896OC DO - 10.1164/rccm.200906-0896OC ID - Moore2010 ER - TY - JOUR AU - Haldar, P. AU - Pavord, I. D. AU - Shaw, D. E. AU - Berry, M. A. AU - Thomas, M. AU - Brightling, C. E. PY - 2008 DA - 2008// TI - Cluster analysis and clinical asthma phenotypes JO - Am J Respir Crit Care Med VL - 178 UR - https://doi.org/10.1164/rccm.200711-1754OC DO - 10.1164/rccm.200711-1754OC ID - Haldar2008 ER - TY - JOUR AU - Pavord, I. D. AU - Korn, S. AU - Howarth, P. AU - Bleecker, E. R. AU - Buhl, R. AU - Keene, O. N. PY - 2012 DA - 2012// TI - Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial JO - Lancet. VL - 380 UR - https://doi.org/10.1016/S0140-6736(12)60988-X DO - 10.1016/S0140-6736(12)60988-X ID - Pavord2012 ER - TY - JOUR AU - Wenzel, S. AU - Ford, L. AU - Pearlman, D. AU - Spector, S. AU - Sher, L. AU - Skobieranda, F. PY - 2013 DA - 2013// TI - Dupilumab in persistent asthma with elevated eosinophil levels JO - N Engl J Med VL - 368 UR - https://doi.org/10.1056/NEJMoa1304048 DO - 10.1056/NEJMoa1304048 ID - Wenzel2013 ER - TY - JOUR AU - Hinks, T. S. AU - Brown, T. AU - Lau, L. C. AU - Rupani, H. AU - Barber, C. AU - Elliott, S. PY - 2016 DA - 2016// TI - Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1 JO - J Allergy Clin Immunol VL - 138 UR - https://doi.org/10.1016/j.jaci.2015.11.020 DO - 10.1016/j.jaci.2015.11.020 ID - Hinks2016 ER - TY - JOUR AU - Chung, K. F. PY - 2013 DA - 2013// TI - New treatments for severe treatment-resistant asthma: targeting the right patient JO - Lancet Respir Med VL - 1 UR - https://doi.org/10.1016/S2213-2600(13)70128-0 DO - 10.1016/S2213-2600(13)70128-0 ID - Chung2013 ER - TY - JOUR AU - Lotvall, J. AU - Akdis, C. A. AU - Bacharier, L. B. AU - Bjermer, L. AU - Casale, T. B. AU - Custovic, A. PY - 2011 DA - 2011// TI - Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome JO - J Allergy Clin Immunol VL - 127 UR - https://doi.org/10.1016/j.jaci.2010.11.037 DO - 10.1016/j.jaci.2010.11.037 ID - Lotvall2011 ER - TY - JOUR AU - Moore, W. C. AU - Bleecker, E. R. AU - Curran-Everett, D. AU - Erzurum, S. C. AU - Ameredes, B. T. AU - Bacharier, L. PY - 2007 DA - 2007// TI - Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's severe Asthma research program JO - J Allergy Clin Immunol VL - 119 UR - https://doi.org/10.1016/j.jaci.2006.11.639 DO - 10.1016/j.jaci.2006.11.639 ID - Moore2007 ER - TY - JOUR AU - Gibeon, D. AU - Heaney, L. G. AU - Brightling, C. E. AU - Niven, R. AU - Mansur, A. H. AU - Chaudhuri, R. PY - 2015 DA - 2015// TI - Dedicated severe asthma services improve health-care use and quality of life JO - Chest. VL - 148 UR - https://doi.org/10.1378/chest.14-3056 DO - 10.1378/chest.14-3056 ID - Gibeon2015 ER - TY - JOUR AU - Sweeney, J. AU - Patterson, C. C. AU - Menzies-Gow, A. AU - Niven, R. M. AU - Mansur, A. H. AU - Bucknall, C. PY - 2016 DA - 2016// TI - Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the optimum patient care research database and the British thoracic difficult Asthma registry JO - Thorax. VL - 71 UR - https://doi.org/10.1136/thoraxjnl-2015-207630 DO - 10.1136/thoraxjnl-2015-207630 ID - Sweeney2016 ER - TY - JOUR AU - Shaw, D. E. AU - Sousa, A. R. AU - Fowler, S. J. AU - Fleming, L. J. AU - Roberts, G. AU - Corfield, J. PY - 2015 DA - 2015// TI - Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort JO - Eur Respir J VL - 46 UR - https://doi.org/10.1183/13993003.00779-2015 DO - 10.1183/13993003.00779-2015 ID - Shaw2015 ER - TY - STD TI - Physicians TRCo. Why Asthma Still Kills - National Review of Asthma Deaths (NRAD) 2014. Available from: https://www.rcplondon.ac.uk/file/868/download?token=JQzyNWUs. Accessed 21 May 2019. UR - https://www.rcplondon.ac.uk/file/868/download?token=JQzyNWUs ID - ref27 ER - TY - STD TI - UK A. Asthma Facts and Statistics 2018. Available from: https://www.asthma.org.uk/about/media/facts-and-statistics/. Accessed 21 May 2019. UR - https://www.asthma.org.uk/about/media/facts-and-statistics/ ID - ref28 ER - TY - STD TI - England N. Research is Everybody’s Business - NHS England Research and Development Strategy 2013 - 2018. Available from: http://www.invo.org.uk/wp-content/uploads/2014/02/NHS-England-Research-Strategy-Consultation.pdf. Accessed 21 May 2019. UR - http://www.invo.org.uk/wp-content/uploads/2014/02/NHS-England-Research-Strategy-Consultation.pdf ID - ref29 ER - TY - JOUR AU - Wanger, J. AU - Clausen, J. L. AU - Coates, A. AU - Pedersen, O. F. AU - Brusasco, V. AU - Burgos, F. PY - 2005 DA - 2005// TI - Standardisation of the measurement of lung volumes JO - Eur Respir J VL - 26 UR - https://doi.org/10.1183/09031936.05.00035005 DO - 10.1183/09031936.05.00035005 ID - Wanger2005 ER - TY - JOUR AU - Heaney, L. G. AU - Brightling, C. E. AU - Menzies-Gow, A. AU - Stevenson, M. AU - Niven, R. M. PY - 2010 DA - 2010// TI - British Thoracic Society difficult Asthma N. refractory asthma in the UK: cross-sectional findings from a UK multicentre registry JO - Thorax. VL - 65 UR - https://doi.org/10.1136/thx.2010.137414 DO - 10.1136/thx.2010.137414 ID - Heaney2010 ER - TY - JOUR AU - McDonald, V. M. AU - Maltby, S. AU - Reddel, H. K. AU - King, G. G. AU - Wark, P. A. AU - Smith, L. PY - 2017 DA - 2017// TI - Severe asthma: current management, targeted therapies and future directions-a roundtable report JO - Respirology. VL - 22 UR - https://doi.org/10.1111/resp.12957 DO - 10.1111/resp.12957 ID - McDonald2017 ER - TY - STD TI - Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society. Am J Respir Crit Care Med. 2000;162:2341–51. https://doi.org/10.1164/ajrccm.162.6.ats9-00. ID - ref33 ER - TY - JOUR AU - Newby, C. AU - Heaney, L. G. AU - Menzies-Gow, A. AU - Niven, R. M. AU - Mansur, A. AU - Bucknall, C. PY - 2014 DA - 2014// TI - Statistical cluster analysis of the British Thoracic Society severe refractory Asthma registry: clinical outcomes and phenotype stability JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0102987 DO - 10.1371/journal.pone.0102987 ID - Newby2014 ER - TY - JOUR AU - Newby, C. AU - Agbetile, J. AU - Hargadon, B. AU - Monteiro, W. AU - Green, R. AU - Pavord, I. PY - 2014 DA - 2014// TI - Lung function decline and variable airway inflammatory pattern: longitudinal analysis of severe asthma JO - J Allergy Clin Immunol VL - 134 UR - https://doi.org/10.1016/j.jaci.2014.04.005 DO - 10.1016/j.jaci.2014.04.005 ID - Newby2014 ER - TY - JOUR AU - Teague, W. G. AU - Phillips, B. R. AU - Fahy, J. V. AU - Wenzel, S. E. AU - Fitzpatrick, A. M. AU - Moore, W. C. PY - 2018 DA - 2018// TI - Baseline features of the severe Asthma research program (SARP III) cohort: differences with age JO - J Allergy Clin Immunol Pract VL - 6 UR - https://doi.org/10.1016/j.jaip.2017.05.032 DO - 10.1016/j.jaip.2017.05.032 ID - Teague2018 ER - TY - JOUR AU - Kuo, C. h. i. h. -. H. s. i. S. c. o. t. t. AU - Pavlidis, S. t. e. l. i. o. s. AU - Loza, M. a. t. t. h. e. w. AU - Baribaud, F. r. e. d. AU - Rowe, A. n. t. h. o. n. y. AU - Pandis, I. a. o. n. n. i. s. AU - Sousa, A. n. a. AU - Corfield, J. u. l. i. e. AU - Djukanovic, R. a. t. k. o. AU - Lutter, R. e. n. e. AU - Sterk, P. e. t. e. r. J. AU - Auffray, C. h. a. r. l. e. s. AU - Guo, Y. i. k. e. AU - Adcock, I. a. n. M. AU - Chung, K. i. a. n. F. a. n. PY - 2017 DA - 2017// TI - T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED JO - European Respiratory Journal VL - 49 UR - https://doi.org/10.1183/13993003.02135-2016 DO - 10.1183/13993003.02135-2016 ID - Kuo2017 ER - TY - JOUR AU - Bigler, J. AU - Boedigheimer, M. AU - Schofield, J. P. R. AU - Skipp, P. J. AU - Corfield, J. AU - Rowe, A. PY - 2017 DA - 2017// TI - A severe Asthma disease signature from gene expression profiling of peripheral blood from U-BIOPRED cohorts JO - Am J Respir Crit Care Med VL - 195 UR - https://doi.org/10.1164/rccm.201604-0866OC DO - 10.1164/rccm.201604-0866OC ID - Bigler2017 ER - TY - JOUR AU - Loza, M. J. AU - Djukanovic, R. AU - Chung, K. F. AU - Horowitz, D. AU - Ma, K. AU - Branigan, P. PY - 2016 DA - 2016// TI - Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study JO - Respir Res VL - 17 UR - https://doi.org/10.1186/s12931-016-0482-9 DO - 10.1186/s12931-016-0482-9 ID - Loza2016 ER - TY - JOUR AU - Walker, S. M. AU - Akdis, C. AU - Dahlen, S. E. PY - 2016 DA - 2016// TI - Building the investment case for asthma R&D: the European Asthma research and innovation partnership argument JO - Clin Exp Allergy VL - 46 UR - https://doi.org/10.1111/cea.12779 DO - 10.1111/cea.12779 ID - Walker2016 ER - TY - JOUR AU - Djukanovic, R. AU - Bruselle, G. AU - Walker, S. PY - 2017 DA - 2017// TI - The era of research collaborations: new models for working together JO - Eur Respir J VL - 49 UR - https://doi.org/10.1183/13993003.01848-2016 DO - 10.1183/13993003.01848-2016 ID - Djukanovic2017 ER -