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Table 4 Historical Clinical Record Data Collection

From: Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH): a pragmatic real-life longitudinal study of difficult asthma in the clinic

Investigations

May Include

Limit of Data Retrieval

Historical Blood Tests

Full blood count (FBC), Total immunoglobulins E, G, M, A (IgE, IgG, IgM, IgA), Aspergillus precipitins (IgG), 25-hydroxy-vitamin D3, Anti-neutrophil cytoplasmic antibody (ANCA), Antinuclear antibody (ANA), Alpha-1-antitrypsin level (A1AT), Urea & electrolytes, Liver profile, Parathyroid hormone (PTH), Thyroid function tests (Thyroid stimulating hormone & Free thyroxine)

10 years

Allergy Testing

Either Skin prick tests or Specific IgE blood tests to common aeroallergens [Aspergillus fumigatus; Alternaria tenius; Cladosporium; Penicillium; Mixed moulds; Grass mix, Birch & Weed mix pollens; Dermatophagoides pteronyssinus and Dermatophagoides farinae; Feathers; Cat & Dog fur; Horse & Rabbit]

10 years

Radiology

Computed Tomography (CT) or High Resolution CT Chest (HRCT), CT sinuses, Dual Energy X-ray Absorptiometry (DEXA) scan

10 years

Oesophageal Investigation Results & History of Interventions

Oesophagogastroduodenoscopy (OGD), Oesophageal Manometry, pH/Impedance testing & surgical history

10 years

ENT Investigation Results & History of Interventions

Nasoendoscopy & surgical history

10 years

Lung Function Tests

Spirometry +/− bronchodilator reversibility

1 year

Fractional exhaled nitric oxide (FeNO)

1 year

Gas transfer

5 years

Impulse oscillometry

1 year

Static lung volumes

1 year

Multiple nitrogen breath washout

1 year