IPAF (n = 54) | CTD-ILD (n = 76) | Seronegative IPF (n = 145) | Seropositive IPF (n = 30) | P-value | |
---|---|---|---|---|---|
Sex (male) (n, %) | 19 (35.2) | 24 (31.6) | 103 (71.0) | 22 (73.3) | < 0.001 |
Mean age (SD) | 67.9 ± 10.5 | 61.6 ± 13.5 | 71.6 ± 9.5 | 71.8 ± 8.3 | < 0.001 |
Ever smoker (n, %) | 15 (27.8) | 23 (30.3) | 95 (65.5) | 20 (66.7) | < 0.001 |
Smoking pack years | 7.0 ± 14.9 | 11.1 ± 20.4 | 24.6 ± 23.1 | 26.7 ± 32.1 | < 0.001 |
ILD pattern from HRCT | < 0.001 | ||||
UIP | 14 (25.9) | 35 (46.1) | 145 (100) | 30 (100) | |
NSIP | 34 (63.0) | 17 (22.4) | 0 (0) | 0 (0) | |
OP | 3 (5.6) | 5 (6.6) | 0 (0) | 0 (0) | |
NSIP + OP | 2 (3.7) | 3 (3.9) | 0 (0) | 0 (0) | |
LIP | 0 (0) | 2 (2.6) | 0 (0) | 0 (0) | |
Emphysema from HRCT (n, %) | 5 (9.3) | 17 (22.4) | 45 (31.0) | 9 (30) | 0.006 |
Lung biopsy at diagnosisa | < 0.001 | ||||
None | 20 (37.0) | 33 (43.4) | 86 (59.3) | 14 (46.7) | |
TBLB | 13 (24.1) | 11 (14.5) | 38 (26.2) | 12 (40) | |
VATS | 25 (46.3) | 21 (27.6) | 18 (12.4) | 9 (30) | |
FVC, L | 2.4 ± 0.7 | 2.6 ± 0.8 | 2.5 ± 0.8 | 2.8 ± 0.9 | 0.063 |
FVC (% of predicted) | 81.8 ± 17.0 | 86.2 ± 18.4 | 80.7 ± 19.1 | 83.8 ± 17.6 | 0.225 |
FEV1, L | 1.9 ± 0.6 | 2.0 ± 0.6 | 2.0 ± 0.6 | 2.2 ± 0.7 | 0.127 |
FEV1/FVC | 82.0 ± 7.7 | 79.1 ± 9.4 | 82.1 ± 8.9 | 79.9 ± 9.6 | 0.109 |
TLC, L | 3.8 ± 1.2 | 4.1 ± 1.0 | 4.4 ± 1.4 | 4.5 ± 1.3 | 0.077 |
TLC (% of predicted) | 87.8 ± 21.6 | 91.1 ± 18.7 | 91.6 ± 24.5 | 84.5 ± 19.0 | 0.434 |
VC,L | 2.4 ± 0.7 | 2.6 ± 0.8 | 2.7 ± 0.8 | 2.8 ± 0.9 | 0.116 |
VC (% of predicted) | 84.5 ± 17.7 | 87.4 ± 19.5 | 80.6 ± 19.2 | 82.0 ± 18.3 | 0.224 |
DLCO (absolute) | 10.6 ± 4.4 | 10.6 ± 3.6 | 11.4 ± 6.0 | 9.7 ± 4.4 | 0.361 |
DLCO (% of predicted) | 62.7 ± 21.0 | 62.3 ± 18.2 | 68.5 ± 24.3 | 57.9 ± 19.0 | 0.059 |