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Table 2 Comparison of clinical characteristics between IPAF, CTD-ILD and IPF

From: Interstitial pneumonia with autoimmune features show better survival and less exacerbations compared to idiopathic pulmonary fibrosis

 

IPAF

(n = 54)

CTD-ILD

(n = 76)

Seronegative IPF

(n = 145)

Seropositive IPF

(n = 30)

P-value

Sex (male) (n, %)

19 (35.2)

24 (31.6)

103 (71.0)

22 (73.3)

< 0.001

Mean age (SD)

67.9 ± 10.5

61.6 ± 13.5

71.6 ± 9.5

71.8 ± 8.3

< 0.001

Ever smoker (n, %)

15 (27.8)

23 (30.3)

95 (65.5)

20 (66.7)

< 0.001

Smoking pack years

7.0 ± 14.9

11.1 ± 20.4

24.6 ± 23.1

26.7 ± 32.1

< 0.001

ILD pattern from HRCT

    

< 0.001

 UIP

14 (25.9)

35 (46.1)

145 (100)

30 (100)

 

 NSIP

34 (63.0)

17 (22.4)

0 (0)

0 (0)

 

 OP

3 (5.6)

5 (6.6)

0 (0)

0 (0)

 

 NSIP + OP

2 (3.7)

3 (3.9)

0 (0)

0 (0)

 

 LIP

0 (0)

2 (2.6)

0 (0)

0 (0)

 

Emphysema from HRCT (n, %)

5 (9.3)

17 (22.4)

45 (31.0)

9 (30)

0.006

Lung biopsy at diagnosisa

    

< 0.001

 None

20 (37.0)

33 (43.4)

86 (59.3)

14 (46.7)

 

 TBLB

13 (24.1)

11 (14.5)

38 (26.2)

12 (40)

 

 VATS

25 (46.3)

21 (27.6)

18 (12.4)

9 (30)

 

FVC, L

2.4 ± 0.7

2.6 ± 0.8

2.5 ± 0.8

2.8 ± 0.9

0.063

FVC (% of predicted)

81.8 ± 17.0

86.2 ± 18.4

80.7 ± 19.1

83.8 ± 17.6

0.225

FEV1, L

1.9 ± 0.6

2.0 ± 0.6

2.0 ± 0.6

2.2 ± 0.7

0.127

FEV1/FVC

82.0 ± 7.7

79.1 ± 9.4

82.1 ± 8.9

79.9 ± 9.6

0.109

TLC, L

3.8 ± 1.2

4.1 ± 1.0

4.4 ± 1.4

4.5 ± 1.3

0.077

TLC (% of predicted)

87.8 ± 21.6

91.1 ± 18.7

91.6 ± 24.5

84.5 ± 19.0

0.434

VC,L

2.4 ± 0.7

2.6 ± 0.8

2.7 ± 0.8

2.8 ± 0.9

0.116

VC (% of predicted)

84.5 ± 17.7

87.4 ± 19.5

80.6 ± 19.2

82.0 ± 18.3

0.224

DLCO (absolute)

10.6 ± 4.4

10.6 ± 3.6

11.4 ± 6.0

9.7 ± 4.4

0.361

DLCO (% of predicted)

62.7 ± 21.0

62.3 ± 18.2

68.5 ± 24.3

57.9 ± 19.0

0.059

  1. Abbreviations: CTD-ILD connective tissue disease-related interstitial lung disease, DLCO Diffusing capacity of the lungs for carbon monoxide, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, HRCT high-resolution computed tomography scan, ILD interstitial lung disease, IPAF interstitial pneumonia with autoimmune features, IPF idiopathic pulmonary fibrosis, LIP lymphocytic interstitial pneumonia, NSIP nonspecific interstitial pneumonia, OP organizing pneumonia, SD standard deviation, TBLB transbronchial lung biopsy, TLC total lung capacity, UIP usual interstitial pneumonia, VATS video-assisted thoracoscopic surgery, VC vital capacity
  2. aSome patients underwent multiple diagnostic procedures