MIND score | Final Number of items | ICCa (N = 114) | Correlations with external measuresb | Comparison of changes in scores from baseline to day 30 – Mean change in score (ESc) | |||||
---|---|---|---|---|---|---|---|---|---|
DNS score (N = 128) | EQ-5D VAS (N = 110) | CGIC = worse (N = 16) | CGIC = stable (N = 54) | CGIC = better (N = 48) | p-value§ | ||||
Component | Cognition | 2 | 0.89 | − 0.50 | 0.31 | − 0.5 (− 0.4) | 0.1 (0.1) | 0.5 (0.3) | < 0.001 |
Feeding/swallowing | 1 | 0.83 | −0.57 | 0.34 | 0.1 (0.0) | 0.1 (0.0) | 1.0 (0.5) | < 0.001 | |
Sleep | 4 | 0.38 | −0.23 | 0.21 | 0.6 (0.5) | −0.2 (− 0.2) | 0.4 (0.4) | 0.011 | |
Skin integrity | 1 | 0.84 | −0.35 | 0.07 | −0.1 (− 0.0) | 0.1 (0.1) | 0.2 (0.1) | 0.519 | |
Oxygenation | 1 | 0.67 | −0.03 | − 0.13 | −0.3 (− 0.2) | 0.2 (0.2) | 0.5 (0.3) | 0.119 | |
Cough strength | 1 | 0.71 | −0.20 | 0.32 | −0.3 (− 0.2) | 0.0 (0.0) | 0.3 (0.1) | 0.415 | |
Secretion management | 1 | 0.70 | −0.27 | 0.06 | −0.3 (− 0.2) | −0.1 (− 0.1) | 0.8 (0.5) | < 0.001 | |
Mobility | 1 | 0.83 | −0.61 | 0.29 | −0.1 (− 0.1) | 0.2 (0.1) | 0.8 (0.5) | < 0.001 | |
Upper limb and lower limb strength | 2 | 0.92 | −0.46 | 0.25 | −0.2 (− 0.2) | 0.2 (0.1) | 0.4 (0.3) | 0.002 | |
Ventilator dependence | 1 | 0.51 | −0.50 | 0.10 | 0.2 (0.1) | 0.1 (0.1) | 1.6 (0.9) | < 0.001 | |
Co-morbidities | 1 | 0.83 | −0.16 | 0.03 | 0.1 (0.0) | 0.1 (0.0) | −0.3 (− 0.2) | 0.125 | |
11-component composite | Simple summation | 16 | 0.83 | −0.76 | 0.38 | −0.7 (− 0.1) | 0.7 (0.1) | 6.1 (0.7) | < 0.001 |
Weighted summation | 16 | 0.89 | −0.71 | 0.46 | −0.8 (− 0.1) | 0.5 (0.0) | 12.3 (0.6) | < 0.001 | |
2-component composite | Simple summation | 2 | 0.83 | −0.58 | 0.46 | −0.2 (− 0.1) | 0.1 (0.0) | 1.3 (0.5) | 0.001 |
Weighted summation | 2 | 0.82 | −0.56 | 0.47 | −0.7 (− 0.1) | 0.3 (0.0) | 3.8 (0.5) | 0.003 |