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Table 5 Validation (test-retest reliability, clinical validity and ability to detect changes) of MIND components and composite scores (N = 128)

From: Validation of the Multi-INdependence Dimensions (MIND) questionnaire for prolonged mechanically ventilated subjects

MIND score

Final Number of items

ICCa (N = 114)

Correlations with external measuresb

Comparison of changes in scores from baseline to day 30 – Mean change in score (ESc)

DNS score (N = 128)

EQ-5D VAS (N = 110)

CGIC = worse (N = 16)

CGIC = stable (N = 54)

CGIC = better (N = 48)

p-value§

Component

Cognition

2

0.89

− 0.50

0.31

− 0.5 (− 0.4)

0.1 (0.1)

0.5 (0.3)

< 0.001

Feeding/swallowing

1

0.83

−0.57

0.34

0.1 (0.0)

0.1 (0.0)

1.0 (0.5)

< 0.001

Sleep

4

0.38

−0.23

0.21

0.6 (0.5)

−0.2 (− 0.2)

0.4 (0.4)

0.011

Skin integrity

1

0.84

−0.35

0.07

−0.1 (− 0.0)

0.1 (0.1)

0.2 (0.1)

0.519

Oxygenation

1

0.67

−0.03

− 0.13

−0.3 (− 0.2)

0.2 (0.2)

0.5 (0.3)

0.119

Cough strength

1

0.71

−0.20

0.32

−0.3 (− 0.2)

0.0 (0.0)

0.3 (0.1)

0.415

Secretion management

1

0.70

−0.27

0.06

−0.3 (− 0.2)

−0.1 (− 0.1)

0.8 (0.5)

< 0.001

Mobility

1

0.83

−0.61

0.29

−0.1 (− 0.1)

0.2 (0.1)

0.8 (0.5)

< 0.001

Upper limb and lower limb strength

2

0.92

−0.46

0.25

−0.2 (− 0.2)

0.2 (0.1)

0.4 (0.3)

0.002

Ventilator dependence

1

0.51

−0.50

0.10

0.2 (0.1)

0.1 (0.1)

1.6 (0.9)

< 0.001

Co-morbidities

1

0.83

−0.16

0.03

0.1 (0.0)

0.1 (0.0)

−0.3 (− 0.2)

0.125

11-component composite

Simple summation

16

0.83

−0.76

0.38

−0.7 (− 0.1)

0.7 (0.1)

6.1 (0.7)

< 0.001

Weighted summation

16

0.89

−0.71

0.46

−0.8 (− 0.1)

0.5 (0.0)

12.3 (0.6)

< 0.001

2-component composite

Simple summation

2

0.83

−0.58

0.46

−0.2 (− 0.1)

0.1 (0.0)

1.3 (0.5)

0.001

Weighted summation

2

0.82

−0.56

0.47

−0.7 (− 0.1)

0.3 (0.0)

3.8 (0.5)

0.003

  1. ICC Intraclass correlation coefficient, ES Effect size, DNS Dependence Nursing Scale, EQ-5D VAS EuroQol-5 Dimension Visual Analogue Scale; CGIC = Clinician Global Impression of Change
  2. aCalculated from baseline to Day 1; Recommended threshold: ICC > 0.70
  3. bPearson correlation coefficient
  4. cES around 0.2: small change; ES around 0.50: moderate change; ES around 0.80: large change
  5. §p-value from ANOVA to compare mean change in score between CGIC worse, stable and better groups