Fig. 4

Treatment effect with tralokinumab Q2W* within biomarker quartile groups (a), and in biomarker-high and -low subgroups defined by cumulative cut-offs (b) in the STRATOS 1 all-comers population (full analysis set). *Estimates within subgroups were based on negative binomial models including treatment group, geographical region, age, number of exacerbations in the previous year, biomarker group and treatment*biomarker group as covariates. The log of each participants’s corresponding follow-up time was used as an offset variable in the model to adjust for participants having different exposure times during which asthma exacerbations occurred. ‘Above’ and ‘below’ in panel B refer to participants with baseline biomarker concentrations falling above and below the indicated cut-off, respectively. The lower CI limits are truncated at − 110%. Two participants with outlier eosinophil values (7,510 and 4,130 cells/μl) were not included in the analyses. The two placebo groups were pooled before the analyses. ^†ng/ml. ^‡Cells/μl. ^§ppb. AAER, annualised asthma exacerbation rate; CI, confidence interval; DPP-4, dipeptidyl peptidase-4; FeNO, fractional exhaled nitric oxide; IgE, immunoglobulin E; Q2W, every 2 weeks