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Fig. 8 | BMC Pulmonary Medicine

Fig. 8

From: Application of structured statistical analyses to identify a biomarker predictive of enhanced tralokinumab efficacy in phase III clinical trials for severe, uncontrolled asthma

Fig. 8

Result of SIDES on permuted data in the STRATOS 1 all-comers population (full analysis set)*. *The plot provides an indication of how SIDES would perform on these data if there was no predictive biomarker. It is computed by permuting the five biomarkers, but removing all predictive (and prognostic) biomarker effects and re-running SIDES. Number of permutations was 500. AAER, annualised asthma exacerbation rate; FeNO, fractional exhaled nitric oxide; SIDES, Subgroup Identification based on Differential Effect Search

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BMC Pulmonary Medicine

ISSN: 1471-2466

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