Fig. 1

Body weights (grams) in adult mice at sacrifice in all the four groups (Open box plots – Room air; shaded box plots – hyperoxia; RAS – room air saline; RAC – room air caffeine; HS – hyperoxia saline; HC – hyperoxia caffeine). Caffeine treated mice had significantly higher body weight at 12wks in hyperoxia (#p < 0.01 vs. HS group, a). Hyperoxic male mice treated with caffeine had significantly higher body weight compared to other groups (**p < 0.001 vs. RAS, RAC & HS groups, b). Caffeinated male mice had significantly higher body weight compared to RA or hyperoxia controls (†p < 0.05 vs. RAS & HS groups). No significant difference in body weight noted in female mice (c). # ** † Fisher’s post-hoc test, ANOVA (n = ten mice per group) (RAS – 6 males, 5 females; RAC – 6 males, 4 females; HS – 5 males, 5 females; HC – 6 males, 4 females)