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Fig. 2 | BMC Pulmonary Medicine

Fig. 2

From: Caffeine is associated with improved alveolarization and angiogenesis in male mice following hyperoxia induced lung injury

Fig. 2

Histopathology of lungs by H&E at 12wks (100x - a,c,e,g; 400x - b,d,f,h in all the four groups (room air saline (RAS)a/b; room air caffeine (RAC)c/d; hyperoxia saline (HS)e/f; hyperoxia caffeine (HC)g/h). Alveoli were numerous in both the RA groups (a/b; c/d); hyperoxia impaired alveolar development with fewer, distended alveoli (E/F) and caffeine restored lung alveolarization (g/h; i/j) (Scale bar: 200 μm (100x), 60 μm (400x)). The radial alveolar count was significantly lower (i) and mean linear intercept was significantly higher (j) in the HS group in both male and female mice suggesting alveolar simplification (Open box plots – RA groups; shaded box plots – hyperoxia groups). *p < 0.001 vs. RAS, RAC & HC groups; Fisher’s post-hoc test, ANOVA (n = ten mice/group)

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