Table 2 Univariate and multivariate Cox regression analysis for factors associated with lung cancer development
Crude hazard ratio (95% CI) | P value | Adjusted hazard ratio (95% CI) | P value | |
|---|---|---|---|---|
Age, years | 1.017 (0.996–1.038) | 0.122 | ||
Gender, male | 4.648 (2.171–9.949) | < 0.001 | 15.956 (2.204–115.496) | 0.006 |
Current smoking | 2.055 (1.460–2.891) | < 0.001 | 1.864 (1.185–2.931) | 0.007 |
FVC < 80% | 0.594 (0.377–0.934) | 0.024 | ||
DLco < 80% | 1.162 (0.777–1.738) | 0.464 | ||
FEV1/FVC < 70% | 1.653 (1.057–2.585) | 0.027 | ||
Decline of FVC ≥ 10%/year | 1.653 (0.981–2.782) | 0.059 | 1.857 (1.014–3.400) | 0.045 |
Decline of DLco ≥15%/year | 0.954 (0.515–1.769) | 0.882 | ||
Use of azathioprine | 0.720 (0.388–1.334) | 0.296 | ||
Use of steroid | 0.843 (0.475–1.493) | 0.558 |