Fig. 1

Kaplan-Meier curves demonstrating the time to first related or unrelated grade 3 or 4 adverse event according to patient HIV status in the matched sample. There were 3 HIV-positive and 42 HIV-negative patients who experienced ≥1 grade 3 or 4 adverse event for whom none of the events had an associated start time, and they were excluded from the KM curve. The hazard ratio for HIV-positive patients experiencing ≥1 grade 3 or 4 adverse event was significantly elevated at 3.25 (95% CI 1.87–5.66, p value < 0.01)