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Table 4 Comparison between each classification of expression and severity of emphysema, presence of COPD, GOLD staging

From: PD-L1, FGFR1, PIK3CA, PTEN, and p16 expression in pulmonary emphysema and chronic obstructive pulmonary disease with resected lung squamous cell carcinoma

  Total severity of emphysema   Local severity of emphysema   Presence of COPD   Staging of GOLD  
Classify of expression none-mild moderate-severe P value none present P value No COPD COPD P value GOLD1 GOLD2,3 P value
PD-L1
 TC0 6 1 0.28 5 2 0.06 3 4 0.72 5 2 0.61
 TC1,2,3 34 18   18 34   26 26   32 20  
 TC0,1 14 5 0.5 9 10 0.36 7 12 0.19 11 8 0.6
 TC2,3 26 14   14 26   22 18   26 14  
 TC0,1,2 20 16 0.012 13 23 0.57 17 19 0.71 22 14 0.75
 TC3 20 3   10 13   12 11   15 8  
 IC0 1 0 0.49 1 0 0.2 0 1 0.32 1 0 0.44
 IC1,2,3 39 19   22 36   29 29   36 22  
 IC0,1 2 0 0.32 2 0 0.07 0 2 0.16 2 0 0.27
 IC2,3 38 19   21 36   29 28   35 22  
 IC0,1,2 20 7 0.34 14 13 0.06 16 11 0.15 18 9 0.56
 IC3 20 12   9 23   13 19   19 13  
FGFR1
 TC0 17 9 0.72 8 18 0.25 13 13 0.91 14 12 0.21
 TC1,2,3 23 10   15 18   16 17   23 10  
PIK3CA
 TC0 36 19 0.15 22 33 0.55 28 27 0.32 33 22 0.11
 TC1,2,3 4 0   1 3   1 3   4 0  
PTEN
 TC0 23 12 0.68 17 18 0.07 16 19 0.52 20 15 0.29
 TC1,2,3 17 7   6 18   13 11   17 7  
p16
 TC0 13 9 0.27 10 12 0.43 14 8 0.09 12 10 0.32
 TC1,2,3 27 10   13 24   15 22   25 12  
  1. COPD Chronic obstructive pulmonary disease, GOLD Global Initiative for Chronic Obstructive Lung Disease, PD-L1 Programmed death ligand 1, TC Tumor cells, IC Immune cells, FGFR1 Fibroblast growth factor receptor 1, PIK3CA Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, PTEN Phosphatase and tensin homolog