Skip to main content

Table 2 Pulmonary function parameters and prognosis indices according to dust exposure at baseline and 12 month treatment

From: Antifibrotic treatment response and prognostic predictors in patients with idiopathic pulmonary fibrosis and exposed to occupational dust

Variablesa

Exposed

(n = 46)b

Not exposed

(n = 43)b

Baseline assessment

12-month assessment

Baseline assessment

12-month assessment

Mean FEV1, L (SD)

2.2 (0.5)

2.1 (0.5)

2.1 (0.6)

2.1 (0.6)

Mean FEV1, % predicted (SD)

89.9 (21.2)

86.8 (19.9)

84.3 (20.3)

80.8 (19.2)

Mean FVC, L (SD)

2.6 (0.6)

2.5 (0.6)

2.5 (0.8)

2.4 (0.8)

Mean FVC, % predicted (SD)

84.0 (19.7)

80.5 (17.8)

76.7 (18.5)

73.7 (18.6)

Mean DLCO, % predicted (SD)

49.4 (14.7)

44.8 (18.0)

47.7 (12.2)

45.6 (13.3)

Mean TLC, L (SD)

4.5 (1.1)

4.3 (1.1)

4.2 (1.2)

4.1 (1.1)

Mean TLC, % predicted (SD)

76.1 (16.9)

71.4 (15.7)

71.8 (14.6)

67.6 (15.9)

GAP score, %

 - 0–3 (IPF stage I)

40.9

31.8

40.5

36.6

 - 4–5 (IPF stage II)

47.7

47.7

52.4

46.3

 - 6–8 (IPF stage III)

11.4

20.5

7.1

17.1

Mean GAP score (SD)

3.8 (1.3)

4.0 (1.5)

3.7 (1.2)

4.0 (1.5)

Mean IPF stage (SD)

1.7 (0.7)

1.9 (0.7)

1.7 (0.6)

1.8 (0.7)

Mean CPI score (SD)

44.9 (12.3)

50.1 (15.1)

47.4 (9.9)

49.1 (11.1)

  1. Exposed = occupational exposure to dust ≥10 years
  2. Not exposed = occupational exposure to dust < 10 years
  3. SD Standard deviation, FEV1 Forced Expiratory Volume at 1st second, FVC Forced Vital Capacity, DLCO Diffusing capacity of the lungs for Carbon Monoxide, TLC Total Lung Capacity, GAP Gender, Age and Physiology, CPI Composite Physiologic Index
  4. aChi-squared test for categorical variables; Kruskal-Wallis test for normally-distributed and non-normally distributed continuous variables, respectively. As all p-values were > 0.05 they were not reported to avoid redundancy
  5. bAnalysis restricted to 89 subjects in pharmacological treatment and with complete respiratory function tests at diagnosis and after 12 months of therapy