Table 3 Relationship between baseline characteristics of the population and FVC and DLCO at 12 month treatment
Variables | FVC% pred. 1-year after treatment | DLCO% pred. 1-year after treatment | ||
|---|---|---|---|---|
Adjusted coeff. (95% CI) | p | Adjusted coeff. (95% CI) | p | |
Mean age at symptoms onset, 10-year increase | −0.04 (− 0.12; 0.03) | 0.2 | 0.17 (− 0.08; 0.43) | 0.2 |
Male gender | 0.44 (0.25; 0.63) | < 0.001 | 3.11 (−3.45; 9.69) | 0.3 |
Mean BMI, 10-point increase | −0.08 (− 0.25; 0.09) | 0.3 | 0.04 (− 0.52; 0.61) | 0.9 |
Smoking status: | ||||
-Cigarette smoke, yes vs no | 0.13 (−0.01; 0.27) | 0.07 | −1.34 (−5.62; 2.94) | 0.5 |
-Mean pack/year, 10-unit increase | −0.01 (− 0.04; 0.02) | 0.5 | − 0.15 (− 1.17; 0.88) | 0.8 |
History of GERD, yes vs no | 0.09 (− 0.06; 0.26) | 0.3 | 0.98 (−4.61; 6.58) | 0.7 |
Familiar history of IPF, yes vs no | 0.00 (−0.21; 0.20) | 0.9 | 2.75 (−3.84; 9.34) | 0.4 |
Exposed vs not exposeda | 0.06 (−0.06; 0.19) | 0.3 | 1.17 (−3.01; 5.17) | 0.6 |
Mean duration of exposure, 10-y increase | −0.00 (− 0.03; 0.03) | 0.9 | − 0.01 (− 0.12; 0.09) | 0.8 |
Asbestos exposure, yes vs no | − 0.04 (− 0.17; 0.09) | 0.6 | −2.76 (− 7.25; 1.73) | 0.2 |
FVC % predicted, 1% increase | ||||
-Baseline FVC | 0.01 (0.01; 0.02) | < 0.001 | −1.96 (−6.47; 2.54) | 0.4 |
-Pre-therapy FVC | 0.02 (0.01; 0.02) | < 0.001 | −0.09 (− 0.23; 0.05) | 0.2 |
DLCO % predicted, 1% increase | ||||
-Baseline DLCO | 0.00 (−0.01; 0.01) | 0.3 | 0.73 (0.52; 0.94) | < 0.001 |
-Pre-therapy DLCO | 0.00 (−0.00; 0.01) | 0.5 | 0.71 (0.51; 0.91) | < 0.001 |
mMRC Breathlessness Scale grade, 1-grade increase | −0.01 (− 0.08; 0.06) | 0.7 | −1.31 (−3.57; − 0.95) | 0.3 |