Table 2 Difference in rate of change per year of FVC, DLCO, and 6MWD per covariate in patients with CTD-ILD

Overall change per year

− 1.4 (− 1.8, − 0.9)

< 0.001

–

–

− 1.8 (− 2.2, − 1.4)

< 0.001

–

–

−9.9 (− 16.0, − 3.8)

0.002

–

–

Age per 10y increase^a

− 0.2 (− 0.6, 0.1)

0.16

− 0.1 (− 0.5, 0.3)

0.62

− 0.4 (− 0.7, 0.0)

0.03

− 0.3 (− 0.7, 0.0)

0.08

−4.5 (− 9.5, 0.5)

0.08

− 3.1 (−8.6, 2.3)

0.26

Male vs. female

− 1.7 (− 2.7, − 0.7)

< 0.001

− 1.9 (− 3.0, − 0.8)

< 0.001

− 1.1 (− 2.1, − 0.1)

0.03

− 1.3 (− 2.4, − 0.3)

0.02

− 26.6 (− 41.0, − 12.2)

< 0.001

− 28.6 (− 44.5, − 12.6)

< 0.001

 Caucasian vs. non-Caucasian

−0.4 (− 1.3, 0.5)

0.40

0.1 (− 1.0, 1.2)

0.86

− 0.5 (− 1.4, 0.5)

0.31

0.4 (− 0.7, 1.5)

0.46

−5.0 (− 21.1, 11.2)

0.55

− 8.8 (− 26.1, 8.4)

0.32

 EA vs. non-EA

0.5 (− 0.6, 1.7)

0.37

0.5 (− 0.8, 1.8)

0.44

0.5 (− 0.7, 1.7)

0.40

0.1 (− 1.2, 1.3)

0.92

0.5 (− 18.9, 20.0)

0.96

− 1.7 (− 21.6, 18.3)

0.87

 SA vs. non-SA

− 1.7 (− 3.3, − 0.1)

0.04

−2.3 (− 4.0, 0.5)

0.010

−0.7 (− 2.4, 1.0)

0.43

−1.9 (− 3.7, − 0.1)

0.04

0.8 (− 24.1, 25.7)

0.95

− 11.6 (− 38.2, 14.9)

0.39

 FN vs. non-FN

1.5 (− 0.4, 3.3)

0.12

0.8 (− 1.2, 2.8)

0.44

0.5 (− 1.3, 2.2)

0.60

0.2 (− 1.7, 2.1)

0.86

0.9 (− 34.3, 36.2)

0.96

5.6 (− 32.0, 43.2)

0.77

Pos. vs. neg. Smoking

− 0.2 (− 1.1, 0.6)

0.61

−0.2 (− 1.1, 0.8)

0.75

−1.0 (− 1.8, − 0.2)

0.02

−1.1 (− 2.0, − 0.2)

0.02

−0.4 (− 12.6, 11.8)

0.95

3.7 (− 10.2, 17.6)

0.60

Income per 10 K increase

−0.2 (− 0.4, 0.0)

0.02

− 0.1 (− 0.3, 0.1)

0.20

−0.1 (− 0.3, 0.0)

0.14

−0.1 (− 0.2, 0.1)

0.55

−1.7 (− 4.3, 1.0)

0.21

−0.2 (− 3.1, 2.7)

0.90

 SSc vs. RA

0.3 (−1.1, 1.7)

0.67

−0.1 (− 2.0, 1.7)

0.90

0.2 (−1.2, 1.6)

0.76

−0.1 (− 2.0, 1.8)

0.93

18.2 (− 12.2, 48.6)

0.24

18.6 (−22.4, 59.5)

0.37

 SSc vs. MCTD

0.0 (−1.7, 1.7)

0.99

0.1 (−1.8, 1.9)

0.96

−0.6 (−2.2, 0.9)

0.43

−0.8 (−2.5, 1.0)

0.40

−17.7 (− 43.0, 7.6)

0.17

− 18.7 (− 45.4, 7.9)

0.17

 SSc vs. other CTD

− 1.0 (− 2.1, 0.1)

0.08

−1.8 (− 3.1, − 0.5)

0.006

−1.5 (− 2.6, − 0.4)

0.007

−2.0 (− 3.2, − 0.7)

0.002

−9.0 (− 31.0, 13.1)

0.43

−23.3 (− 47.9, 1.2)

0.06

Baseline value^a (per 10%-predicted / 100 m decrease)

0.0 (− 0.2, 0.2)

0.93

0.1 (− 0.2, 0.3)

0.69

0.2 (0.0, 0.4)

0.09

0.2 (− 0.1, 0.4)

0.14

2.5 (−3.2, 8.3)

0.39

3.5 (−2.8, 9.8)

0.28

UIP vs. NSIP

−0.9 (−2.4, 0.6)

0.23

− 0.7 (− 2.3, 0.9)

0.39

0.1 (− 1.4, 1.6)

0.88

0.6 (− 1.1, 2.2)

0.49

− 28.9 (− 50.7, − 7.0)

0.010

− 24.2 (− 46.9, − 1.5)

0.04