Severe community-acquired pneumonia in general medical wards: outcomes and impact of initial antibiotic selection

BMC Pulmonary Medicine

Table 5 Risk factors for Infectious Diseases Society of America/American Thoracic Society Guideline – discordant initial antibiotic selection

	Guidelines Concordance (n = 54)	Guidelines Discordance (n = 40)	p-value
Age, y	68.5 ± 15.9	71.3 ± 19.6	.44
Gender (Female)	28 (51.8)	9 (22.5)	.004*
Severe community-acquired pneumonia	24 (44.4)	26 (65)	.048*
Comorbid conditions:
None	17 (31.5)	9 (22.5)	.5
Single	22 (40.7)	16 (40)
Multiple	15 (27.8)	15 (37.5)
Prior antibiotic therapy^a	20 (37)	23 (57.5)	.049*
ECOG ≥2^b	28 (51.8)	26 (65)	.2
Enteral tube feeding	2 (3.7)	7 (17.5)	.03*
Healthcare–associated pneumonia	11 (20.4)	19 (47.5)	.005*
Pleural effusion	11 (20.4)	0	.002*
Initial antibiotic treatment:
Nonantipseudomonas β-lactams	42 (77.8)	10 (25)	<.001*
Antipseudomonas β-lactams	3 (5.6)	24 (60)	<.001*
Macrolide	43 (79.6)	2 (5)	<.001*
Quinolone	11 (20.4)	5 (12.5)	.31

Data are presented as mean ± SD or n (%), unless otherwise stated
^aPrior antibiotic therapy: systemic antibiotic use in the 90 days prior to this admission. ^bECOG scale: Eastern Cooperative Oncology Group scale of performance status. *Statistically significant difference

ISSN: 1471-2466