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Table 3 Clinical factors associated with all-cause mortality (univariate analysis)

From: Combined pulmonary fibrosis and emphysema and idiopathic pulmonary fibrosis in non-small cell lung cancer: impact on survival and acute exacerbation

Variables

HR

95% CI

P value

BMI, kg/m2

0.92

0.88–0.96

<  0.001

Ever Smoker, Yes

0.897

0.55–1.46

0.897

CPFE, yes

0.995

0.75–1.32

0.972

NSCLC Stage ≥ III

3.68

2.69–5.03

<  0.001

ECOG

1.44

1.24–1.68

<  0.001

AE, Yes

2.91

1.73–4.91

<  0.001

GAP Score

1.50

1.33–1.70

<  0.001

Sex, Male

0.971

0.54–1.74

0.920

FVC, % Predicted

0.98

0.98–0.99

< 0.001

FEV1, % Predicted

0.97

0.96–0.98

< 0.001

DLco, % Predicted

0.98

0.98–0.99

<  0.001

FEV1/FVC, %

1.03

1.01–1.04

0.004

Time Gap between Diagnosis of IPF or CPFE and Diagnosis of NSCLC, months

1.00

1.00–1.01

0.265

Histologic type

 Adenocarcinoma

1.00

  

 Squamous cell carcinoma

0.93

0.69–1.26

0.647

 Others

1.68

1.10–2.55

0.016

  1. Data are presented as hazard ratios (95% confidence intervals)
  2. Definition of abbreviations: BMI Body Mass Index, CPFE Combined Pulmonary Fibrosis and Emphysema, NSCLC Non-Small Cell Lung Cancer, ECOG Eastern Cooperative Oncology Group performance status, AE Acute Exacerbation, GAP Score Gender–Age–Physiology Score, FVC Forced Vital Capacity, FEV1 forced expiratory volume in 1 s, DLCO diffusing capacity of carbon monoxide