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Table 1 Results of the pooled and subgroup analyses for the ADRB2 rs1042713 polymorphism and asthma risk

From: Association of β2-adrenergic receptor gene polymorphisms (rs1042713, rs1042714, rs1042711) with asthma risk: a systematic review and updated meta-analysis

Variable

n

Case/Control

Dominant model comparison

Recessive model comparison

Homozygote genotype comparison

Allelic comparison

Frequency of minor allele (A/(A + G))

OR[95%CI]

P(Z)

I2

OR[95%CI]

P(Z)

I2

OR[95%CI]

P(Z)

I2

OR[95%CI]

P(Z)

I2

Case

Control

Total

71

12,070/21669

1.08 [0.97, 1.21]

0.165

68%

1.05 [0.94, 1.18]

0.387

70%

1.10 [0.95, 1.27]

0.201

70%

1.02 [0.95, 1.10]

0.591

74%

0.494

0.443

Adult

36

6984/15697

1.12 [0.97, 1.28]

0.122

62%

1.05 [0.92, 1.19]

0.447

58%

1.12 [0.96, 1.32]

0.160

56%

1.06 [0.98, 1.15]

0.131

56%

0.485

0.430

Children

26

4539/5320

1.13 [0.93, 1.38]

0.210

72%

1.07 [0.85, 1.35]

0.570

79%

1.13 [0.85, 1.51]

0.400

79%

1.00 [0.85, 1.17]

0.976

84%

0.510

0.478

East-Asian

36

6343/6291

1.00 [0.87, 1.16]

0.966

63%

1.04 [0.87, 1.26]

0.645

71%

1.03 [0.84, 1.26]

0.801

67%

1.02 [0.93, 1.13]

0.677

69%

0.539

0.533

Indian

5

1190/1241

0.72 [0.59, 0.87]

0.001

25%

0.91 [0.69, 1.19]

0.480

54%

0.72 [0.51, 1.03]

0.070

53%

0.84 [0.69, 1.02]

0.073

60%

0.477

0.437

Arab

2

307/361

1.75 [1.14, 2.70]

0.011

0%

1.17 [0.59, 2.30]

0.654

69%

1.88 [1.17, 3.02]

0.009

35%

0.83 [0.34, 2.02]

0.165

51%

0.360

0.436

Hispanic-Latinos

5

1026/1412

1.68 [1.10, 2.55]

0.016

77%

1.64 [0.86, 3.14]

0.133

90%

2.09 [0.98, 4.45]

0.055

64%

0.99 [0.60, 1.63]

0.970

94%

0.464

0.481

non-Hispanic Blacks

5

671/556

1.55 [0.70, 3.42]

0.282

80%

1.22 [0.68, 2.19]

0.498

52%

1.40 [0.64, 3.06]

0.401

64%

0.70 [0.55, 0.89]

0.529

85%

0.529

0.532

Caucasian

16

2892/11950

1.05 [0.87, 1.25]

0.620

36%

0.96 [0.83, 1.11]

0.541

35%

1.01 [0.87, 1.16]

0.946

32%

0.99 [0.89, 1.10]

0.847

46%

0.430

0.389

HWE(P > 0.05)

49

9752/19296

0.99 [0.87, 1.13]

0.890

70%

0.97 [0.85, 1.10]

0.598

73%

0.98 [0.81, 1.16]

0.716

76%

0.98 [0.90, 1.07]

0.653

78%

0.486

0.431

HWE(P < 0.05)

18

2366/2320

1.22 [0.96, 1.55]

0.240

55%

1.17 [0.94, 1.44]

0.164

50%

1.17 [0.99, 1.38]

0.055

29%

1.15 [1.01, 1.30]

0.031

48%

0.520

0.541

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