Fig. 4

Ex vivo lung function depending on age. Respiratory mechanics of normoxic PND120 and PND280 mice recorded by use of a buffer-perfused isolated lung system. Pleural pressure-TV relations indicate the lung compliance (a). Peak airflow values are given at the pleural pressure-related TVs (b). For data presentation we used minimum values recorded shortly prior to the deep inspiration performed every 3 min and resultant values for the normal respiratory volume of mice (10 μl TV·g BW^− 1). All data are means ± SD (n ≥ 12) with ^**P ≤ 0.01 between the PND groups. BW, body weight; TV, tidal volume