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Fig. 5 | BMC Pulmonary Medicine

Fig. 5

From: Severe but not moderate hyperoxia of newborn mice causes an emphysematous lung phenotype in adulthood without persisting oxidative stress and inflammation

Fig. 5

Ex vivo lung function after neonatal hyperoxia. Respiratory mechanics of PND120 mice treated with different concentrations of oxygen until PND14 were recorded by use of a buffer-perfused lung system. These parameters are the lung compliance presented by the pleural pressure-TV relations (a) and the peak airflow values recorded at the pleural pressure-related TVs (b). For data calculation we used minimum values recorded shortly prior to the deep inspiration performed every 3 min and resultant values for the normal respiratory volume of mice (10 μl TV·g BW− 1). The mean airway resistance at 70% TV (c) and the pulmonary artery pressures (d) as mean (left) and in dependence on changes in the perfusion flow (right) are given when the ventilation was performed at normal respiratory volume. Lung wet-to-dry ratio indicates the edema formation after lung ex vivo analysis (e). All data are means ± SD (n ≥ 16 each group) with *P ≤ 0.05 and **P ≤ 0.01 vs. N group. BW, body weight; TV, tidal volume; PAP, pulmonary artery pressure per atmospheric pressure

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